TY - JOUR
T1 - Design, preparation and in vitro characterizations of fluconazole loaded nanostructured lipid carriers
AU - Fernandes, Amanda Velinna
AU - Pydi, Chinna Raja
AU - Verma, Ruchi
AU - Jose, Jobin
AU - Kumar, Lalit
PY - 2020/1/1
Y1 - 2020/1/1
N2 - Present study was aimed to prepare and characterize fluconazole loaded nanostructured lipid carriers (FLZ-NLCs) for the treatment of fungal infections. Fungal infections are tremendously widespread and are the often faced dermatological condition worldwide. FLZ-NLCs was prepared by ultrasonication emulsion technique using stearic acid (SA) as solid lipid, castor oil as liquid lipid and tween 20 as a surfactant. The mean diameter of optimized FLZ-NLCs were found to be 359.15 ± 9.83 nm. The drug content and entrapment efficiency of NLCs was found to be 102.97 ± 7.45% and 87 ± 0.59%, respectively. In vitro drug release studies of FLZ-NLCs showed 37.34 ± 2.08% drug release over a period of 72 h. The above studies confirmed the prepared FLZ-NLCs may be useful for the treatment of fungal infections.
AB - Present study was aimed to prepare and characterize fluconazole loaded nanostructured lipid carriers (FLZ-NLCs) for the treatment of fungal infections. Fungal infections are tremendously widespread and are the often faced dermatological condition worldwide. FLZ-NLCs was prepared by ultrasonication emulsion technique using stearic acid (SA) as solid lipid, castor oil as liquid lipid and tween 20 as a surfactant. The mean diameter of optimized FLZ-NLCs were found to be 359.15 ± 9.83 nm. The drug content and entrapment efficiency of NLCs was found to be 102.97 ± 7.45% and 87 ± 0.59%, respectively. In vitro drug release studies of FLZ-NLCs showed 37.34 ± 2.08% drug release over a period of 72 h. The above studies confirmed the prepared FLZ-NLCs may be useful for the treatment of fungal infections.
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U2 - 10.1590/s2175-97902019000318069
DO - 10.1590/s2175-97902019000318069
M3 - Article
AN - SCOPUS:85081645693
SN - 1984-8250
VL - 56
JO - Revista de Farmacia e Bioquimica da Universidade de Sao Paulo
JF - Revista de Farmacia e Bioquimica da Universidade de Sao Paulo
M1 - e18069
ER -