TY - JOUR
T1 - Design, Synthesis and Evaluation of Antitubercular Activity of Novel 1,2,4-Triazoles Against MDR Strain of Mycobacterium tuberculosis
AU - Ganesh Kumar, T. N.V.
AU - Gautham Shenoy, G.
AU - Kar, Sidhartha Sankar
AU - Shenoy, Vishnu
AU - Bairy, Indira
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Emergence of various forms of resistant strains of Mycobacterium tuberculosis led to the exploration of drugs with novel mechanism of action. Recently econazole, an azole based antitubercular agent, attracted major attention for targeting mycobacterial cytochrome P450. In the present study, we designed novel 1,2,4-triazole derivatives based on econazole moiety and evaluated them for in vitro antitubercular activity against M. tuberculosis H37Rv and multi-drug resistant (MDR) strains of Mycobacterium.
AB - Emergence of various forms of resistant strains of Mycobacterium tuberculosis led to the exploration of drugs with novel mechanism of action. Recently econazole, an azole based antitubercular agent, attracted major attention for targeting mycobacterial cytochrome P450. In the present study, we designed novel 1,2,4-triazole derivatives based on econazole moiety and evaluated them for in vitro antitubercular activity against M. tuberculosis H37Rv and multi-drug resistant (MDR) strains of Mycobacterium.
UR - http://www.scopus.com/inward/record.url?scp=85041106006&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85041106006&partnerID=8YFLogxK
U2 - 10.1007/s11094-018-1714-8
DO - 10.1007/s11094-018-1714-8
M3 - Article
AN - SCOPUS:85041106006
SN - 0091-150X
VL - 51
SP - 907
EP - 917
JO - Pharmaceutical Chemistry Journal
JF - Pharmaceutical Chemistry Journal
IS - 10
ER -
