Design, Synthesis and Evaluation of Antitubercular Activity of Novel 1,2,4-Triazoles Against MDR Strain of Mycobacterium tuberculosis

T. N.V. Ganesh Kumar; G. Gautham Shenoy; Sidhartha Sankar Kar; Vishnu Shenoy; Indira Bairy

doi:10.1007/s11094-018-1714-8

Design, Synthesis and Evaluation of Antitubercular Activity of Novel 1,2,4-Triazoles Against MDR Strain of Mycobacterium tuberculosis

T. N.V. Ganesh Kumar^*
, G. Gautham Shenoy
, Sidhartha Sankar Kar
, Vishnu Shenoy
, Indira Bairy

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Emergence of various forms of resistant strains of Mycobacterium tuberculosis led to the exploration of drugs with novel mechanism of action. Recently econazole, an azole based antitubercular agent, attracted major attention for targeting mycobacterial cytochrome P450. In the present study, we designed novel 1,2,4-triazole derivatives based on econazole moiety and evaluated them for in vitro antitubercular activity against M. tuberculosis H37Rv and multi-drug resistant (MDR) strains of Mycobacterium.

Original language	English
Pages (from-to)	907-917
Number of pages	11
Journal	Pharmaceutical Chemistry Journal
Volume	51
Issue number	10
DOIs	https://doi.org/10.1007/s11094-018-1714-8
Publication status	Published - 01-01-2018

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Pharmacology
Drug Discovery

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10.1007/s11094-018-1714-8

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title = "Design, Synthesis and Evaluation of Antitubercular Activity of Novel 1,2,4-Triazoles Against MDR Strain of Mycobacterium tuberculosis",

abstract = "Emergence of various forms of resistant strains of Mycobacterium tuberculosis led to the exploration of drugs with novel mechanism of action. Recently econazole, an azole based antitubercular agent, attracted major attention for targeting mycobacterial cytochrome P450. In the present study, we designed novel 1,2,4-triazole derivatives based on econazole moiety and evaluated them for in vitro antitubercular activity against M. tuberculosis H37Rv and multi-drug resistant (MDR) strains of Mycobacterium.",

author = "\{Ganesh Kumar\}, \{T. N.V.\} and \{Gautham Shenoy\}, G. and Kar, \{Sidhartha Sankar\} and Vishnu Shenoy and Indira Bairy",

note = "Publisher Copyright: {\textcopyright} 2018, Springer Science+Business Media, LLC, part of Springer Nature.",

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AU - Ganesh Kumar, T. N.V.

AU - Gautham Shenoy, G.

AU - Kar, Sidhartha Sankar

AU - Shenoy, Vishnu

AU - Bairy, Indira

PY - 2018/1/1

Y1 - 2018/1/1

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AB - Emergence of various forms of resistant strains of Mycobacterium tuberculosis led to the exploration of drugs with novel mechanism of action. Recently econazole, an azole based antitubercular agent, attracted major attention for targeting mycobacterial cytochrome P450. In the present study, we designed novel 1,2,4-triazole derivatives based on econazole moiety and evaluated them for in vitro antitubercular activity against M. tuberculosis H37Rv and multi-drug resistant (MDR) strains of Mycobacterium.

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UR - https://www.scopus.com/pages/publications/85041106006#tab=citedBy

U2 - 10.1007/s11094-018-1714-8

DO - 10.1007/s11094-018-1714-8

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JO - Pharmaceutical Chemistry Journal

JF - Pharmaceutical Chemistry Journal

IS - 10

ER -

Design, Synthesis and Evaluation of Antitubercular Activity of Novel 1,2,4-Triazoles Against MDR Strain of Mycobacterium tuberculosis

Abstract

UN SDGs

All Science Journal Classification (ASJC) codes

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