@article{3946cc41d0954c82b813014c2c6e14b2,
title = "Design, synthesis, and evaluation of novel 6-chloro-/fluorochromone derivatives as potential topoisomerase inhibitor anticancer agents",
abstract = "6-Chloro-2-pyrrolidino-/morpholino-/piperidino-/N-methylpiperazino-3- formyl-chromones (13-16) and 6-fluoro-2,7-di-morpholino-/piperidino-/N- methylpiperazino-3-formylchromones (17-19) have been synthesized as potential topoisomerase inhibitor anticancer agents, and evaluated, in vitro, against Ehrlich ascites carcinoma (EAC) cells, and also in vivo on EAC bearing mice. The compounds displayed promising anticancer activity under these test systems and shall serve as useful 'leads' for further design. {\textcopyright} 2005 Elsevier Ltd. All rights reserved.",
author = "M.P.S. Ishar and G. Singh and S. Singh and K.K. Sreenivasan",
note = "Cited By :74 Export Date: 10 November 2017 CODEN: BMCLE Correspondence Address: Ishar, M.P.S.; Department of Pharmaceutical Sciences, Guru Nanak Dev University, Amritsar 143 005, Punjab, India; email: mpsishar@yahoo.com Chemicals/CAS: Antineoplastic Agents; Chromones; DNA Topoisomerases, EC 5.99.1.-; Enzyme Inhibitors References: Champaux, J., (1990) DNA Topology and Its Biological Effects, p. 217. , J.C. Wang N.R. Cozarelli Cold Spring Harbor Laboratory Cold Spring Harbor, NY; Hsieh, T.-S., (1990) DNA Topology and Its Biological Effects, p. 243. , J.C. Wang N.R. Cozarelli Cold Spring Harbor Laboratory Cold Spring Harbor, NY; Caserta, M., Amadei, A., Camilloni, G., Di Mauro, E., (1990) Biochemistry, 29, p. 8152; Harrnon, F.G., Digate, R.J., Kowalczykowski, S.C., (1999) Mol. Cell, 3, p. 611; Nagarajan, M., Morrell, A., Fort, B.C., Meckley, M.R., Antony, S., Kholhagen, G., Pommier, Y., Cushman, M., (2004) J. Med. Chem., 47, p. 5651; Pommier, Y., Tanizawa, A., (1993) Cancer Chemotherapy, p. 214. , J. Hickman T. Tritton Blackwell Scientific Publications Oxford; Chen, A.U., Liu, L.F., (1994) Annu. Rev. Pharmacol. Toxicol., 94, p. 194; Zewail-Foote, M., Hurley, L., (1999) Anti-Cancer Drug Des., 14, p. 1; Levine, C., Hiasa, H., Marians, K.J., (1998) Biochim. Biophys. Acta, 1400, p. 29; Potmesil, M., Kohn, K.K., (1991) Topoisomerases in Cancer, , Oxford University Press: New York, Chapter 2; Osheroff, N., (1989) Pharmacol. Ther., 41, p. 223; Spicer, J., Finlay, G., Baguley, B., Velea, L., Graves, D., Denny, W., (1999) Anti-Cancer Drug Des., 14, p. 37; Gootz, T.D., Birghty, K.E., (1998) The Quinolones, p. 29. , V.T. Andriole 2nd ed. Academic Press San Diego; Hooper, D.C., (2001) Clin. Infect. Dis., 32, p. 9; Fan, J.-Y., Sun, D., Yu, H., Kerwin, S.M., Hurley, L.H., (1995) J. Med. Chem., 38, p. 408; Laco, G.S., Du, W., Kohlhagen, G., Sayer, J.M., Jerina, D.M., Burke, T.G., Curran, D.P., Pommier, Y., (2004) Biorg. Med. Chem., 12, p. 5225; Cianchetta, G., Mannhold, R., Cruciani, G., Baroni, M., Cecchetti, V., (2004) J. Med. Chem., 47, p. 3193; Hsiang, Y.-H., Hertzberg, R., Hecht, S., Liu, L.F., (1985) J. Biol. Chem., 260, p. 14873; Mhaske, S.B., Argade, N.P., (2004) J. Org. Chem., 69, p. 4563; Nagarajan, M., Xiao, X., Antony, S., Kohlhagen, G., Pommier, Y., Cushman, M., (2003) J. Med. Chem., 46, p. 5712; Wall, M.E., (1998) Med. Res. Rev., 18, p. 299; Cragg, G.M., Newman, D.J., (2004) J. Nat. Prod., 67, p. 232; Osheroff, N., Zechiedrich, E.L., Gale, K.C., (1991) BioEssays, 13, p. 269; Rahier, N.J., Eisenhauer, B.M., Gao, R., Jones, S.H., Shannon, R.G., Hecht, S.M., (2004) Org. Lett., 6, p. 321; Arimondo, P., Boukarim, C., Bailly, C., Dauzonne, D., Monneret, C., (2000) Anti-Cancer Drug Des., 15, p. 413; Xiao, Z., Vance, J.R., Bastow, K.F., Brossi, A., Wang, H.-K., Lee, K.-H., (2004) Bioorg. Med. Chem. Lett., 12, p. 3363; Cassady, J.M., Baird, W.M., Chang, C.J., (1990) J. Nat. Prod., 53, p. 23; Kupchan, S.M., Streelman, D.R., Sneden, A.T., (1980) J. Nat. Prod., 43, p. 296; Kim, M.Y., Na, Y., Vankayalapati, H., Gleason-Guzman, M., (2003) J. Med. Chem., 46, p. 2958; Kwok, Y., Sun, D., Clement, J., Hurley, L., (1999) Anti-Cancer Drug Des., 14, p. 443; Domagala, J.M., (1994) J. Antimicrob. Chemother., 33, p. 685; Bryskier, A., Chantot, J.-F., (1995) Drugs, 49 (SUPPL. 2), p. 16; Gootz, T.D., Brighty, K.E., (1996) Med. Res. Rev., 16, p. 433; Xia, Y., Yang, Z.-Y., Xia, P., Hackl, T., Hamel, E., Mauger, A., Wu, J.-H., Lee, K.-H., (2001) J. Med. Chem., 44, p. 3932; Ishar, M.P.S., Kumar, K., Singh, R., (1998) Tetrahedron Lett., 39, p. 6547; Singh, G., Singh, R., Girdhar, N.K., Ishar, M.P.S., (2002) Tetraherdon, 58, p. 2471; Singh, G., Singh, L., Ishar, M.P.S., (2002) Tetraherdon, 58, p. 7883; note; note; Gupta, M., Mazumder, U.K., Kumar, R.S., Kumar, T.S., (2004) Acta Pharmacol. Sin., 25, p. 1070; Bhattacharyya, A., Choudhuri, T., Pal, S., Chattopadhyay, S., Datta, G.K., Sa, G., Das, T., (2003) Carcinogensis, 24, p. 75; note; note; Lowry, O.H., Roesebrough, N.J., Farr, A.L., Randall, R.J., (1951) J. Biol. Chem., 193, p. 265; Moron, M.S., Depierre, J.W., Mannervik, B., (1979) Biochim. Biophys. Acta, 5820, p. 62; note; Yagi, K., (1991) Chem. Phys. Lipids, 45, p. 337; Sinclair, A.J., Barnett, A.H., Lunie, J., (1990) Br. J. Hosp. Med., 43, p. 334",
year = "2006",
doi = "10.1016/j.bmcl.2005.11.044",
language = "English",
volume = "16",
pages = "1366--1370",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Limited",
number = "5",
}