TY - JOUR
T1 - DESIGNING OF STABLE CO-CRYSTALS OF AZITHROMYCIN USING SUITABLE COFORMERS
AU - Srinivas, Poojary Pooja
AU - Prabhu, Nishank
AU - Vasantharaju, S. G.
AU - Patel, Neel
AU - Pai, Aravind
AU - Pai, Vasudev
AU - Sathyanarayana, Muddukrishna Badamane
N1 - Publisher Copyright:
© 2022, Rasayan Journal of Chemistry, c/o Dr. Pratima Sharma. All rights reserved.
PY - 2022/10/1
Y1 - 2022/10/1
N2 - In this present study, a new co-crystal of azithromycin with nicotinamide and naringenin has been developed with improved solubility. Azithromycin is a class II drug with poor aqueous solubility; hence an attempt has been made to improve its solubility through co-crystallization technology. In this study, the coformers selected were nicotinamide and naringenin based on ease of hydrogen bond formation. The co-crystal of azithromycin with nicotinamide was prepared in three ratios (1:1, 1:2, and 2:1) by dry grinding and slow solvent evaporation method. The co-crystal of azithromycin with naringenin was prepared in three ratios (1:1, 1:2, and 2:1) by dry grinding and slow solvent evaporation method. The formation of the co-crystal was confirmed by Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), and powder X-ray diffractometry (PXRD). Azithromycin-Nicotinamide cocrystal 1:1 prepared by the dry grinding method was increased by 6.85 fold as compared to pure drug. Azithromycin-Naringenin cocrystal 1:1 prepared by solvent evaporation method was increased by 3.06 fold as compared to pure drug.
AB - In this present study, a new co-crystal of azithromycin with nicotinamide and naringenin has been developed with improved solubility. Azithromycin is a class II drug with poor aqueous solubility; hence an attempt has been made to improve its solubility through co-crystallization technology. In this study, the coformers selected were nicotinamide and naringenin based on ease of hydrogen bond formation. The co-crystal of azithromycin with nicotinamide was prepared in three ratios (1:1, 1:2, and 2:1) by dry grinding and slow solvent evaporation method. The co-crystal of azithromycin with naringenin was prepared in three ratios (1:1, 1:2, and 2:1) by dry grinding and slow solvent evaporation method. The formation of the co-crystal was confirmed by Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), and powder X-ray diffractometry (PXRD). Azithromycin-Nicotinamide cocrystal 1:1 prepared by the dry grinding method was increased by 6.85 fold as compared to pure drug. Azithromycin-Naringenin cocrystal 1:1 prepared by solvent evaporation method was increased by 3.06 fold as compared to pure drug.
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U2 - 10.31788/RJC.2022.1546985
DO - 10.31788/RJC.2022.1546985
M3 - Article
AN - SCOPUS:85145424203
SN - 0974-1496
VL - 15
SP - 2417
EP - 2428
JO - Rasayan Journal of Chemistry
JF - Rasayan Journal of Chemistry
IS - 4
ER -