TY - JOUR
T1 - Designing of Stable Co-crystals of Clotrimazole using suitable Coformers
AU - Prabhu, Nishank
AU - Srinivas, Poojary Pooja
AU - Ravi, Gundawar
AU - Pai, Aravind
AU - Pai, Girish
AU - Pai, Vasudev
AU - Vasanthraju, S. G.
AU - Sathyanarayana, Muddukrishna Badamane
N1 - Publisher Copyright:
© RJPT All right reserved.
PY - 2024
Y1 - 2024
N2 - The present study involves the preparation of co-crystal forms of clotrimazole with co-formers namely nicotinic acid and naringenin. Clotrimazole is a BCS class II drug withlow solubility and high permeability. Hence by preparing the co-crystal, an attempt has been made to improve its solubility. Based on thehydrogen bond formation between the API and co-former, two co-formers were selected: nicotinic acid and naringenin. The co-crystals of clotrimazole with nicotinic acid and naringenin were prepared in the molar ratios of 1:1, 1:2, and 2:1 using dry grinding and solvent evaporation. PXRD, DSC and FTIR confirmed the formation of co-crystals. The solubility of co-crystals of clotrimazole with nicotinic acid was increased 2.07 folds for the ratios 1:2 prepared by solvent evaporation method compared to pure clotrimazole. The saturation solubility was also increased for the co-crystals of clotrimazole with naringenin by 2 folds for the ratio 2:1 prepared by solvent evaporation method compared to pure clotrimazole.
AB - The present study involves the preparation of co-crystal forms of clotrimazole with co-formers namely nicotinic acid and naringenin. Clotrimazole is a BCS class II drug withlow solubility and high permeability. Hence by preparing the co-crystal, an attempt has been made to improve its solubility. Based on thehydrogen bond formation between the API and co-former, two co-formers were selected: nicotinic acid and naringenin. The co-crystals of clotrimazole with nicotinic acid and naringenin were prepared in the molar ratios of 1:1, 1:2, and 2:1 using dry grinding and solvent evaporation. PXRD, DSC and FTIR confirmed the formation of co-crystals. The solubility of co-crystals of clotrimazole with nicotinic acid was increased 2.07 folds for the ratios 1:2 prepared by solvent evaporation method compared to pure clotrimazole. The saturation solubility was also increased for the co-crystals of clotrimazole with naringenin by 2 folds for the ratio 2:1 prepared by solvent evaporation method compared to pure clotrimazole.
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U2 - 10.52711/0974-360X.2024.00403
DO - 10.52711/0974-360X.2024.00403
M3 - Article
AN - SCOPUS:85200797118
SN - 0974-3618
VL - 17
SP - 2580
EP - 2586
JO - Research Journal of Pharmacy and Technology
JF - Research Journal of Pharmacy and Technology
IS - 6
ER -