TY - JOUR
T1 - Determination of racecadotril by HPLC in capsules
AU - Prabu, S.
AU - Singh, T.
AU - Joseph, A.
AU - Kumar, C.
AU - Shirwaikar, A.
N1 - Cited By :6
Export Date: 10 November 2017
CODEN: IJSID
Correspondence Address: Shirwaikar, A.; Department of Pharmaceutics, Gulf Pharmacy College, Gulf Medical University, Ajman, United Arab Emirates; email: [email protected]
Chemicals/CAS: acetonitrile, 75-05-8; acetorphan, 81110-73-8; gemfibrozil, 25812-30-0
Manufacturers: Reddy Research Foundation, India; Sun, India
References: Matheson, A.J., Noble, S., Discussions (2000) Drugs, 59, p. 829; Cezard JP, Salazar-Lindo E. Racecadotril in acute diarrhea. Indian Pediatr 2005;42:502-3; Schwartz JC. Racecadotril, a new approach to the treatment of diarrhea. J Antimicrob Agents 2000;14:75-9UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-40749107091&partnerID=40&md5=fd47d9856692da602127fd9fc2d02c66
PY - 2007
Y1 - 2007
N2 - A simple, precise and rapid RP-HPLC method was developed for the determination of racecadotril in a pharmaceutical formulation using gemfibrozil as internal standard. Ratio of the peak area of analyte to internal standard was used for quantification. The chromatographic separation was carried out by using a Reverse Phase C18 column (BDS-Hypersil). The mobile phase consisting of a mixture of 20 mM phosphate buffer (pH 3.5) and acetonitrile in the ratio of (40:60) with detection at 230 nm at a flow rate of 1 ml/min was employed. The method was statistically validated for linearity, accuracy and precision. The elution time was 6.9 min for racecadotril and 9.8 min for gemfibrozil. The simplicity and accuracy of the proposed method ensures its use in routine quality control analysis of pharmaceutical formulations.
AB - A simple, precise and rapid RP-HPLC method was developed for the determination of racecadotril in a pharmaceutical formulation using gemfibrozil as internal standard. Ratio of the peak area of analyte to internal standard was used for quantification. The chromatographic separation was carried out by using a Reverse Phase C18 column (BDS-Hypersil). The mobile phase consisting of a mixture of 20 mM phosphate buffer (pH 3.5) and acetonitrile in the ratio of (40:60) with detection at 230 nm at a flow rate of 1 ml/min was employed. The method was statistically validated for linearity, accuracy and precision. The elution time was 6.9 min for racecadotril and 9.8 min for gemfibrozil. The simplicity and accuracy of the proposed method ensures its use in routine quality control analysis of pharmaceutical formulations.
M3 - Article
SN - 0250-474X
VL - 69
SP - 819
EP - 821
JO - Indian Journal of Pharmaceutical Sciences
JF - Indian Journal of Pharmaceutical Sciences
IS - 6
ER -