Development and validation of diclofenac sodium in tablets using simple UV spectrophotometric method

Ragini V. Mane; Kritika Patel; Gude Sai Sushmitha; S. G. Vasantharaju

doi:10.5958/0974-360X.2019.00108.2

Development and validation of diclofenac sodium in tablets using simple UV spectrophotometric method

Ragini V. Mane, Kritika Patel, Gude Sai Sushmitha, S. G. Vasantharaju

Department of Pharmaceutical Quality Assurance, Manipal College of Pharmaceutical Sciences, Manipal

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

An effective and simple UV-Spectrophotometric method was developed and validated for the quantification of Diclofenac sodium in tablets. The maximum absorption was found to be 282nm by using methanol as the solvent. The linearity range was 6-21 µg/ml and the correlation coefficient (r²) was found to be 0.9985. The method was accurate, precise, and robust with %RSD below 2%. The LOD and LOQ was found to be 0.0885µg/Ml and 0.250µg/mL respectively. Sandel’s sensitivity was found to be 0.000002 µg/mL. Assay and accuracy of the tablets were about of the acceptance criteria range as per the ICH guidelines.

Original language	English
Pages (from-to)	611-614
Number of pages	4
Journal	Research Journal of Pharmacy and Technology
Volume	12
Issue number	2
DOIs	https://doi.org/10.5958/0974-360X.2019.00108.2
Publication status	Published - 01-02-2019

All Science Journal Classification (ASJC) codes

Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
Pharmacology (medical)

Access to Document

10.5958/0974-360X.2019.00108.2

Cite this

@article{529739d5f80a47d1940717faadf78bdb,

title = "Development and validation of diclofenac sodium in tablets using simple UV spectrophotometric method",

abstract = "An effective and simple UV-Spectrophotometric method was developed and validated for the quantification of Diclofenac sodium in tablets. The maximum absorption was found to be 282nm by using methanol as the solvent. The linearity range was 6-21 µg/ml and the correlation coefficient (r2) was found to be 0.9985. The method was accurate, precise, and robust with %RSD below 2%. The LOD and LOQ was found to be 0.0885µg/Ml and 0.250µg/mL respectively. Sandel{\textquoteright}s sensitivity was found to be 0.000002 µg/mL. Assay and accuracy of the tablets were about of the acceptance criteria range as per the ICH guidelines.",

author = "Mane, {Ragini V.} and Kritika Patel and Sushmitha, {Gude Sai} and Vasantharaju, {S. G.}",

year = "2019",

month = feb,

day = "1",

doi = "10.5958/0974-360X.2019.00108.2",

language = "English",

volume = "12",

pages = "611--614",

journal = "Research Journal of Pharmacy and Technology",

issn = "0974-3618",

publisher = "A and V Publication",

number = "2",

}

TY - JOUR

T1 - Development and validation of diclofenac sodium in tablets using simple UV spectrophotometric method

AU - Mane, Ragini V.

AU - Patel, Kritika

AU - Sushmitha, Gude Sai

AU - Vasantharaju, S. G.

PY - 2019/2/1

Y1 - 2019/2/1

N2 - An effective and simple UV-Spectrophotometric method was developed and validated for the quantification of Diclofenac sodium in tablets. The maximum absorption was found to be 282nm by using methanol as the solvent. The linearity range was 6-21 µg/ml and the correlation coefficient (r2) was found to be 0.9985. The method was accurate, precise, and robust with %RSD below 2%. The LOD and LOQ was found to be 0.0885µg/Ml and 0.250µg/mL respectively. Sandel’s sensitivity was found to be 0.000002 µg/mL. Assay and accuracy of the tablets were about of the acceptance criteria range as per the ICH guidelines.

AB - An effective and simple UV-Spectrophotometric method was developed and validated for the quantification of Diclofenac sodium in tablets. The maximum absorption was found to be 282nm by using methanol as the solvent. The linearity range was 6-21 µg/ml and the correlation coefficient (r2) was found to be 0.9985. The method was accurate, precise, and robust with %RSD below 2%. The LOD and LOQ was found to be 0.0885µg/Ml and 0.250µg/mL respectively. Sandel’s sensitivity was found to be 0.000002 µg/mL. Assay and accuracy of the tablets were about of the acceptance criteria range as per the ICH guidelines.

UR - http://www.scopus.com/inward/record.url?scp=85073447829&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85073447829&partnerID=8YFLogxK

U2 - 10.5958/0974-360X.2019.00108.2

DO - 10.5958/0974-360X.2019.00108.2

M3 - Article

AN - SCOPUS:85073447829

SN - 0974-3618

VL - 12

SP - 611

EP - 614

JO - Research Journal of Pharmacy and Technology

JF - Research Journal of Pharmacy and Technology

IS - 2

ER -

Development and validation of diclofenac sodium in tablets using simple UV spectrophotometric method

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this