Development of cream to enhance the antifungal activity and reduce the side effects of fluconazole for the treatment of Candida albicans

Navya Ajitkumar Bhaskaran, Salwa, Amanda Velinna Fernandes, Gabriela Volfová, Chinna Raja Pydi, Lalit Kumar, Ruchi Verma, Shirleen Miriam Marques, Rupesh Kalidas Shirodkar

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)

Abstract

The aim of the present study was to formulate a fluconazole cream for the treatment of Candida albicans. The optimized cream formulation was prepared using stearic acid, oleic acid, beeswax and borax. The uniform distribution of the active ingredient fluconazole could be confirmed in all formulated creams. The FC-C-C formulation showed satisfactory spreadability and extrudability. FC-C-C delivered (95.07 ± 15.85)% in only 36 h, and the formulation released the drug by an anomalous diffusion mechanism. The viscosity of FC-C-C was found to be (63.20 ± 0.83) cP. The antifungal study and animal studies confirmed that the prepared formulation is non-irritant and has an enhanced antifungal activity that reduces the side effects of fluconazole. The studies confirm that the prepared formulation may be useful for the treatment of Candida albicans.

Original languageEnglish
Pages (from-to)231-239
Number of pages9
JournalTenside, Surfactants, Detergents
Volume59
Issue number3
DOIs
Publication statusPublished - 05-2022

All Science Journal Classification (ASJC) codes

  • General Chemistry
  • General Chemical Engineering
  • Condensed Matter Physics

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