TY - JOUR
T1 - Dexmedetomidine versus ketamine infusion to alleviate propofol injection pain
T2 - A prospective randomized and double-blind study
AU - Thukral, Seema
AU - Gupta, Priyanka
AU - Lakra, Archana
AU - Gupta, Mayank
N1 - Publisher Copyright:
© 2015 Indian Journal of Anaesthesia.
Copyright:
Copyright 2015 Elsevier B.V., All rights reserved.
PY - 2015/8/1
Y1 - 2015/8/1
N2 - Background and Aims: The use of propofol as the most common induction agent and the high prevalence of propofol injection pain (PIP) highlight the significance of finding the ideal combination of drug, dosage and mode of administration of premedicants to alleviate PIP. A number of bolus drugs with variable efficacy have been studied to reduce PIP. The aim of our study was to assess the efficacy of single dose intravenous (IV) infusion of dexmedetomidine 0.5 µg/kg compared with ketamine 0.5 mg/kg to alleviate PIP. Methods: In this prospective, randomised and double-blind study, 108 patients undergoing elective surgeries under general anaesthesia were randomly allocated to two groups: Group D to receive dexmedetomidine 0.5µg/ kg or Group K to receive ketamine 0.5 mg/kg in 20 ml of normal saline over 10 min. Immediately after the infusion, 1% propofol 2 mg/kg IV was injected over 25 s. The patients were assessed for pain every 5 s by asking the question ‘does it hurt?’ until the loss of consciousness. The pain scoring was done using McCririck and Hunter scale. Statistical analysis was done using SPSS 17.0. Results: The incidence of PIP and moderate-severe PIP was higher with Group D (79.6%; 16.7%) compared with Group K (40.7; 1.9%) (P < 0.001; 0.016). No patient in either group had arm withdrawal upon propofol injection. The incidence of hypertension and tachycardia was statistically significant in Group K as compared to Group D (P = 0.027). Conclusion: There was no difference in elimination of the arm withdrawal response and in incidence of moderate to severe PIP between the groups.
AB - Background and Aims: The use of propofol as the most common induction agent and the high prevalence of propofol injection pain (PIP) highlight the significance of finding the ideal combination of drug, dosage and mode of administration of premedicants to alleviate PIP. A number of bolus drugs with variable efficacy have been studied to reduce PIP. The aim of our study was to assess the efficacy of single dose intravenous (IV) infusion of dexmedetomidine 0.5 µg/kg compared with ketamine 0.5 mg/kg to alleviate PIP. Methods: In this prospective, randomised and double-blind study, 108 patients undergoing elective surgeries under general anaesthesia were randomly allocated to two groups: Group D to receive dexmedetomidine 0.5µg/ kg or Group K to receive ketamine 0.5 mg/kg in 20 ml of normal saline over 10 min. Immediately after the infusion, 1% propofol 2 mg/kg IV was injected over 25 s. The patients were assessed for pain every 5 s by asking the question ‘does it hurt?’ until the loss of consciousness. The pain scoring was done using McCririck and Hunter scale. Statistical analysis was done using SPSS 17.0. Results: The incidence of PIP and moderate-severe PIP was higher with Group D (79.6%; 16.7%) compared with Group K (40.7; 1.9%) (P < 0.001; 0.016). No patient in either group had arm withdrawal upon propofol injection. The incidence of hypertension and tachycardia was statistically significant in Group K as compared to Group D (P = 0.027). Conclusion: There was no difference in elimination of the arm withdrawal response and in incidence of moderate to severe PIP between the groups.
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U2 - 10.4103/0019-5049.162987
DO - 10.4103/0019-5049.162987
M3 - Article
AN - SCOPUS:84939245353
SN - 0019-5049
VL - 59
SP - 488
EP - 492
JO - Indian Journal of Anaesthesia
JF - Indian Journal of Anaesthesia
IS - 8
ER -