TY - JOUR
T1 - Distal sensory polyneuropathy in human immunodeficiency virus patients and nucleoside analogue antiretroviral agents
AU - Jose, Jimmy
AU - Saravu, Kavitha
AU - Jimmy, Beena
AU - Shastry, B.
PY - 2007/4/1
Y1 - 2007/4/1
N2 - Distal sensory polyneuropathy, which occur commonly in human immunodeficiency virus (HIV) patients can occur as a consequence of the disease itself or the antiretroviral treatment the patient is receiving. Among the antiretroviral agents, nucleoside analogues are commonly associated with neuropathy and the main underlying mechanism is thought to be the mitochondrial toxicity exhibited by these agents. Clinical presentation of antiretroviral induced neuropathy is similar to that associated with the HIV infection and in many patients they may overlap. Treatment is primarily symptomatic and certain pathogenesis-based approaches have shown promising results.
AB - Distal sensory polyneuropathy, which occur commonly in human immunodeficiency virus (HIV) patients can occur as a consequence of the disease itself or the antiretroviral treatment the patient is receiving. Among the antiretroviral agents, nucleoside analogues are commonly associated with neuropathy and the main underlying mechanism is thought to be the mitochondrial toxicity exhibited by these agents. Clinical presentation of antiretroviral induced neuropathy is similar to that associated with the HIV infection and in many patients they may overlap. Treatment is primarily symptomatic and certain pathogenesis-based approaches have shown promising results.
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U2 - 10.4103/0972-2327.33214
DO - 10.4103/0972-2327.33214
M3 - Review article
AN - SCOPUS:34447136003
SN - 0972-2327
VL - 10
SP - 81
EP - 87
JO - Annals of Indian Academy of Neurology
JF - Annals of Indian Academy of Neurology
IS - 2
ER -
