Distribution of mesenchymal stem cell-derived exosomes in the intact and injured brain following intranasal administration

Olagide W. Castro; Maheedhar Kodali; Raghavendra Upadhya; Dong Ki Kim; Bing Shuai; Darwin J. Prockop; A. K. Shetty

Distribution of mesenchymal stem cell-derived exosomes in the intact and injured brain following intranasal administration

Olagide W. Castro
, Maheedhar Kodali
, Raghavendra Upadhya
, Dong Ki Kim
, Bing Shuai
, Darwin J. Prockop
, A. K. Shetty

Department of Biotherapeutics Research (DBR)

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

xosomes generated from human bone marrow derived mesenchymal stem cells (hMSCs) display antiinflammatory and neuroprotective activity of hMSCs. Our recent study in a model of status epilepticus (SE) has shown that intranasally (IN) administered hMSC-derived A1-exosomes reach different parts of the brain including the hippocampus within 6 hours (Long et al., PNAS, 2017).

Original language	English
Title of host publication	Distribution of mesenchymal stem cell-derived exosomes in the intact and injured brain following intranasal administration
Publisher	Society for Neuroscience
Publication status	Published - 15-11-2017

Cite this

Castro, O. W., Kodali, M., Upadhya, R., Kim, D. K., Shuai, B., Prockop, D. J., & Shetty, A. K. (2017). Distribution of mesenchymal stem cell-derived exosomes in the intact and injured brain following intranasal administration. In Distribution of mesenchymal stem cell-derived exosomes in the intact and injured brain following intranasal administration Society for Neuroscience.

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title = "Distribution of mesenchymal stem cell-derived exosomes in the intact and injured brain following intranasal administration",

abstract = "xosomes generated from human bone marrow derived mesenchymal stem cells (hMSCs) display antiinflammatory and neuroprotective activity of hMSCs. Our recent study in a model of status epilepticus (SE) has shown that intranasally (IN) administered hMSC-derived A1-exosomes reach different parts of the brain including the hippocampus within 6 hours (Long et al., PNAS, 2017). ",

author = "Castro, \{Olagide W.\} and Maheedhar Kodali and Raghavendra Upadhya and Kim, \{Dong Ki\} and Bing Shuai and Prockop, \{Darwin J.\} and Shetty, \{A. K.\}",

year = "2017",

month = nov,

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booktitle = "Distribution of mesenchymal stem cell-derived exosomes in the intact and injured brain following intranasal administration",

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Distribution of mesenchymal stem cell-derived exosomes in the intact and injured brain following intranasal administration. / Castro, Olagide W.; Kodali, Maheedhar; Upadhya, Raghavendra et al.
Distribution of mesenchymal stem cell-derived exosomes in the intact and injured brain following intranasal administration. Society for Neuroscience, 2017.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - Distribution of mesenchymal stem cell-derived exosomes in the intact and injured brain following intranasal administration

AU - Castro, Olagide W.

AU - Kodali, Maheedhar

AU - Upadhya, Raghavendra

AU - Kim, Dong Ki

AU - Shuai, Bing

AU - Prockop, Darwin J.

AU - Shetty, A. K.

PY - 2017/11/15

Y1 - 2017/11/15

N2 - xosomes generated from human bone marrow derived mesenchymal stem cells (hMSCs) display antiinflammatory and neuroprotective activity of hMSCs. Our recent study in a model of status epilepticus (SE) has shown that intranasally (IN) administered hMSC-derived A1-exosomes reach different parts of the brain including the hippocampus within 6 hours (Long et al., PNAS, 2017).

AB - xosomes generated from human bone marrow derived mesenchymal stem cells (hMSCs) display antiinflammatory and neuroprotective activity of hMSCs. Our recent study in a model of status epilepticus (SE) has shown that intranasally (IN) administered hMSC-derived A1-exosomes reach different parts of the brain including the hippocampus within 6 hours (Long et al., PNAS, 2017).

UR - https://www.abstractsonline.com/pp8/#!/4376/presentation/9295

M3 - Conference contribution

BT - Distribution of mesenchymal stem cell-derived exosomes in the intact and injured brain following intranasal administration

PB - Society for Neuroscience

ER -

Distribution of mesenchymal stem cell-derived exosomes in the intact and injured brain following intranasal administration

Abstract

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