Distribution of mesenchymal stem cell-derived exosomes in the intact and injured brain following intranasal administration

Olagide W. Castro; Maheedhar Kodali; Raghavendra Upadhya; Dong Ki Kim; Bing Shuai; Darwin J. Prockop; A. K. Shetty

Distribution of mesenchymal stem cell-derived exosomes in the intact and injured brain following intranasal administration

Olagide W. Castro, Maheedhar Kodali, Raghavendra Upadhya, Dong Ki Kim, Bing Shuai, Darwin J. Prockop, A. K. Shetty

Department of Biotherapeutics Research (DBR)

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

xosomes generated from human bone marrow derived mesenchymal stem cells (hMSCs) display antiinflammatory and neuroprotective activity of hMSCs. Our recent study in a model of status epilepticus (SE) has shown that intranasally (IN) administered hMSC-derived A1-exosomes reach different parts of the brain including the hippocampus within 6 hours (Long et al., PNAS, 2017).

Original language	English
Title of host publication	Distribution of mesenchymal stem cell-derived exosomes in the intact and injured brain following intranasal administration
Publisher	Society for Neuroscience
Publication status	Published - 15-11-2017

Cite this

Castro, O. W., Kodali, M., Upadhya, R., Kim, D. K., Shuai, B., Prockop, D. J., & Shetty, A. K. (2017). Distribution of mesenchymal stem cell-derived exosomes in the intact and injured brain following intranasal administration. In Distribution of mesenchymal stem cell-derived exosomes in the intact and injured brain following intranasal administration Society for Neuroscience.

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title = "Distribution of mesenchymal stem cell-derived exosomes in the intact and injured brain following intranasal administration",

abstract = "xosomes generated from human bone marrow derived mesenchymal stem cells (hMSCs) display antiinflammatory and neuroprotective activity of hMSCs. Our recent study in a model of status epilepticus (SE) has shown that intranasally (IN) administered hMSC-derived A1-exosomes reach different parts of the brain including the hippocampus within 6 hours (Long et al., PNAS, 2017). ",

author = "Castro, \{Olagide W.\} and Maheedhar Kodali and Raghavendra Upadhya and Kim, \{Dong Ki\} and Bing Shuai and Prockop, \{Darwin J.\} and Shetty, \{A. K.\}",

year = "2017",

month = nov,

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booktitle = "Distribution of mesenchymal stem cell-derived exosomes in the intact and injured brain following intranasal administration",

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Distribution of mesenchymal stem cell-derived exosomes in the intact and injured brain following intranasal administration. / Castro, Olagide W.; Kodali, Maheedhar; Upadhya, Raghavendra et al.
Distribution of mesenchymal stem cell-derived exosomes in the intact and injured brain following intranasal administration. Society for Neuroscience, 2017.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - Distribution of mesenchymal stem cell-derived exosomes in the intact and injured brain following intranasal administration

AU - Castro, Olagide W.

AU - Kodali, Maheedhar

AU - Upadhya, Raghavendra

AU - Kim, Dong Ki

AU - Shuai, Bing

AU - Prockop, Darwin J.

AU - Shetty, A. K.

PY - 2017/11/15

Y1 - 2017/11/15

N2 - xosomes generated from human bone marrow derived mesenchymal stem cells (hMSCs) display antiinflammatory and neuroprotective activity of hMSCs. Our recent study in a model of status epilepticus (SE) has shown that intranasally (IN) administered hMSC-derived A1-exosomes reach different parts of the brain including the hippocampus within 6 hours (Long et al., PNAS, 2017).

AB - xosomes generated from human bone marrow derived mesenchymal stem cells (hMSCs) display antiinflammatory and neuroprotective activity of hMSCs. Our recent study in a model of status epilepticus (SE) has shown that intranasally (IN) administered hMSC-derived A1-exosomes reach different parts of the brain including the hippocampus within 6 hours (Long et al., PNAS, 2017).

UR - https://www.abstractsonline.com/pp8/#!/4376/presentation/9295

M3 - Conference contribution

BT - Distribution of mesenchymal stem cell-derived exosomes in the intact and injured brain following intranasal administration

PB - Society for Neuroscience

ER -

Distribution of mesenchymal stem cell-derived exosomes in the intact and injured brain following intranasal administration

Abstract

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