DNA promoter methylation-dependent transcription of the double C2-like domain β (DOC2B) gene regulates tumor growth in human cervical cancer

Shama Prasada Kabekkodu, Samatha Bhat, Raghu Radhakrishnan, Abhijit Aithal, Roshan Mascarenhas, Deeksha Pandey, Lavanya Rai, Pralhad Kushtagi, Gopinath Puthiya Mundyat, Kapaettu Satyamoorthy

Research output: Contribution to journalArticlepeer-review

36 Citations (Scopus)

Abstract

Background: DOC2B promoter hypermethylation is an early and frequent event in cervical cancer. Results: DOC2B hypermethylation induces transcriptional repression, reactivated by demethylation; ectopic expression increases Ca 2+ flux and inhibits key characteristics of tumorigenesis including proliferation, motility, and invasion. Conclusion: DOC2B gene is epigenetically regulated and inhibits cervical cancer growth. Significance: DNA methylation regulates DOC2B gene expression in cervical cancer.

Original languageEnglish
Pages (from-to)10637-10649
Number of pages13
JournalJournal of Biological Chemistry
Volume289
Issue number15
DOIs
Publication statusPublished - 11-04-2014

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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