DNA promoter methylation-dependent transcription of the double C2-like domain β (DOC2B) gene regulates tumor growth in human cervical cancer

Shama Prasada Kabekkodu; Samatha Bhat; Raghu Radhakrishnan; Abhijit Aithal; Roshan Mascarenhas; Deeksha Pandey; Lavanya Rai; Pralhad Kushtagi; Gopinath Puthiya Mundyat; Kapaettu Satyamoorthy

doi:10.1074/jbc.M113.491506

DNA promoter methylation-dependent transcription of the double C2-like domain β (DOC2B) gene regulates tumor growth in human cervical cancer

Shama Prasada Kabekkodu
, Samatha Bhat
, Raghu Radhakrishnan
, Abhijit Aithal
, Roshan Mascarenhas
, Deeksha Pandey
, Lavanya Rai
, Pralhad Kushtagi
, Gopinath Puthiya Mundyat
, Kapaettu Satyamoorthy^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

40 Citations (Scopus)

Abstract

Background: DOC2B promoter hypermethylation is an early and frequent event in cervical cancer. Results: DOC2B hypermethylation induces transcriptional repression, reactivated by demethylation; ectopic expression increases Ca ²⁺ flux and inhibits key characteristics of tumorigenesis including proliferation, motility, and invasion. Conclusion: DOC2B gene is epigenetically regulated and inhibits cervical cancer growth. Significance: DNA methylation regulates DOC2B gene expression in cervical cancer.

Original language	English
Pages (from-to)	10637-10649
Number of pages	13
Journal	Journal of Biological Chemistry
Volume	289
Issue number	15
DOIs	https://doi.org/10.1074/jbc.M113.491506
Publication status	Published - 11-04-2014

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology
Cell Biology

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10.1074/jbc.M113.491506

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Kabekkodu, S. P., Bhat, S., Radhakrishnan, R., Aithal, A., Mascarenhas, R., Pandey, D., Rai, L., Kushtagi, P., Mundyat, G. P., & Satyamoorthy, K. (2014). DNA promoter methylation-dependent transcription of the double C2-like domain β (DOC2B) gene regulates tumor growth in human cervical cancer. Journal of Biological Chemistry, 289(15), 10637-10649. https://doi.org/10.1074/jbc.M113.491506

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title = "DNA promoter methylation-dependent transcription of the double C2-like domain β (DOC2B) gene regulates tumor growth in human cervical cancer",

abstract = "Background: DOC2B promoter hypermethylation is an early and frequent event in cervical cancer. Results: DOC2B hypermethylation induces transcriptional repression, reactivated by demethylation; ectopic expression increases Ca 2+ flux and inhibits key characteristics of tumorigenesis including proliferation, motility, and invasion. Conclusion: DOC2B gene is epigenetically regulated and inhibits cervical cancer growth. Significance: DNA methylation regulates DOC2B gene expression in cervical cancer.",

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Kabekkodu, SP , Bhat, S , Radhakrishnan, R, Aithal, A, Mascarenhas, R, Pandey, D, Rai, L, Kushtagi, P, Mundyat, GP & Satyamoorthy, K 2014, 'DNA promoter methylation-dependent transcription of the double C2-like domain β (DOC2B) gene regulates tumor growth in human cervical cancer', Journal of Biological Chemistry, vol. 289, no. 15, pp. 10637-10649. https://doi.org/10.1074/jbc.M113.491506

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T1 - DNA promoter methylation-dependent transcription of the double C2-like domain β (DOC2B) gene regulates tumor growth in human cervical cancer

AU - Kabekkodu, Shama Prasada

AU - Bhat, Samatha

AU - Radhakrishnan, Raghu

AU - Aithal, Abhijit

AU - Mascarenhas, Roshan

AU - Pandey, Deeksha

AU - Rai, Lavanya

AU - Kushtagi, Pralhad

AU - Mundyat, Gopinath Puthiya

AU - Satyamoorthy, Kapaettu

PY - 2014/4/11

Y1 - 2014/4/11

N2 - Background: DOC2B promoter hypermethylation is an early and frequent event in cervical cancer. Results: DOC2B hypermethylation induces transcriptional repression, reactivated by demethylation; ectopic expression increases Ca 2+ flux and inhibits key characteristics of tumorigenesis including proliferation, motility, and invasion. Conclusion: DOC2B gene is epigenetically regulated and inhibits cervical cancer growth. Significance: DNA methylation regulates DOC2B gene expression in cervical cancer.

AB - Background: DOC2B promoter hypermethylation is an early and frequent event in cervical cancer. Results: DOC2B hypermethylation induces transcriptional repression, reactivated by demethylation; ectopic expression increases Ca 2+ flux and inhibits key characteristics of tumorigenesis including proliferation, motility, and invasion. Conclusion: DOC2B gene is epigenetically regulated and inhibits cervical cancer growth. Significance: DNA methylation regulates DOC2B gene expression in cervical cancer.

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DNA promoter methylation-dependent transcription of the double C2-like domain β (DOC2B) gene regulates tumor growth in human cervical cancer

Abstract

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