TY - JOUR
T1 - Dose-dependent increase in the frequency of micronuclei and chromosomal aberrations by misonidazole in mouse bone marrow
AU - Bisht, Kheem Singh
AU - Uma Devi, Pathirissery
PY - 1994/1/1
Y1 - 1994/1/1
N2 - Cytogenetic effects produced in bone marrow of mice by various doses of misonidazole (MISO, 100 to 1000 mg/kg bodyweight) were studied by assaying the induction of micronuclei (MN) and chromosomal aberrations. Misonidazole increased the frequency of both micronuclei and chromosomal aberrations over normal at 24 h after treatment, however, the values were statistically significant from normal only at drug doses above 250 mg/kg. The increase was proportional to the drug dose with a best fit to linear quadratic model for MN induction. For chromosomal aberrations the data fitted eqully well to linear as well as linear quadratic models.
AB - Cytogenetic effects produced in bone marrow of mice by various doses of misonidazole (MISO, 100 to 1000 mg/kg bodyweight) were studied by assaying the induction of micronuclei (MN) and chromosomal aberrations. Misonidazole increased the frequency of both micronuclei and chromosomal aberrations over normal at 24 h after treatment, however, the values were statistically significant from normal only at drug doses above 250 mg/kg. The increase was proportional to the drug dose with a best fit to linear quadratic model for MN induction. For chromosomal aberrations the data fitted eqully well to linear as well as linear quadratic models.
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U2 - 10.1016/0165-7992(94)90002-7
DO - 10.1016/0165-7992(94)90002-7
M3 - Article
SN - 0165-7992
VL - 325
SP - 57
EP - 63
JO - Mutation Research Letters
JF - Mutation Research Letters
IS - 2-3
ER -