TY - JOUR
T1 - Dried spot sample and its drug detection using LC-MS/MS
T2 - Trends and advances in matrix collection and bioanalytics
AU - Sathyanarayanan, Arpita
AU - Somashekara, Divyashree Mysore
N1 - Funding Information:
The authors are thankful to Mr. Ramesh P. Ahir, Manager, and Mr. Shreyas Patel, Deputy Manager, Department of Bioanalytical, Zydus Cadila—Cadila Healthcare Limited, for their guidance and without their support this project would not have been possible. Funding There is no funding to report
Publisher Copyright:
© 2022. Sathyanarayanan and Somashekara. This is an open access article distributed under the terms of the Creative Commons Attribution 4.0 International License (https://creativecommons.org/licenses/by/4.0/)
PY - 2022/6
Y1 - 2022/6
N2 - Therapeutic drug monitoring involves the clinical study of the drug and its metabolite in a biological matrix amidst the existing endogenous substances. One of the key components in performing therapeutic drug monitoring is the biological matrix. The collection and storage of biological matrix have developed rapidly in the last few decades. Dried blood spot (DBS) is a method which was introduced in the 1960s and has gone through series of advanced till date. These involve use of filter paper or punch cards to harvest and store blood for further use. One of the major disadvantages of DBS is the influence of hematocrit values in drug collections therefore paving way for dried plasma spot detection (DPS). Use of DBS and DPS is a growing trend observed in the sample collection. In the last few years, many assays have been developed based on this technique this paper introduced the pross and cons of DBS and DPS while looking into the advances in the drug detection using these matrixes.
AB - Therapeutic drug monitoring involves the clinical study of the drug and its metabolite in a biological matrix amidst the existing endogenous substances. One of the key components in performing therapeutic drug monitoring is the biological matrix. The collection and storage of biological matrix have developed rapidly in the last few decades. Dried blood spot (DBS) is a method which was introduced in the 1960s and has gone through series of advanced till date. These involve use of filter paper or punch cards to harvest and store blood for further use. One of the major disadvantages of DBS is the influence of hematocrit values in drug collections therefore paving way for dried plasma spot detection (DPS). Use of DBS and DPS is a growing trend observed in the sample collection. In the last few years, many assays have been developed based on this technique this paper introduced the pross and cons of DBS and DPS while looking into the advances in the drug detection using these matrixes.
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U2 - 10.7324/JAPS.2022.120602
DO - 10.7324/JAPS.2022.120602
M3 - Article
AN - SCOPUS:85131419853
SN - 2231-3354
VL - 12
SP - 11
EP - 22
JO - Journal of Applied Pharmaceutical Science
JF - Journal of Applied Pharmaceutical Science
IS - 6
ER -