Early Curcumin Treatment After Exposure to Blast Shock Waves Prevents Long-term Cognitive and Memory Impairments and Maintains Higher Levels of Hippocampal Neurogenesis.

Raghavendra Upadhya, UPADHYA D, Bharathi Hattiangady, A ROBBINS, Maheedhar Kodali, Bing Shuai, Adrian Bates, M MORENO, A. K. Shetty

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Exposure to blast shock waves (SWs) underlies a significant fraction of combat related mild traumatic brain injury incurred by Operation Iraqi Freedom and Operation Enduring Freedom Veterans. Mild traumatic brain injury resulting from the exposure to blast SWs leads to cognitive, and memory dysfunction over variable time-periods depending upon the severity of the exposure. These impairments are likely linked to evolving neuroinflammation and decreased hippocampal neurogenesis. We investigated whether 7 days of curcumin treatment starting 2 hours after an exposure to SWs of a single blast can block hippocampus-dependent cognitive and memory impairments and restrain adverse alterations in the hippocampus, at an extended time-point after exposure.
Original languageEnglish
Title of host publicationEarly curcumin treatment after exposure to blast shock waves prevents long-term cognitive and memory impairments and maintains higher levels of hippocampal neurogenesis
PublisherSociety for Neuroscience
Publication statusPublished - 15-11-2017

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