Early Curcumin Treatment After Exposure to Blast Shock Waves Prevents Long-term Cognitive and Memory Impairments and Maintains Higher Levels of Hippocampal Neurogenesis.

Raghavendra Upadhya; UPADHYA D; Bharathi Hattiangady; A ROBBINS; Maheedhar Kodali; Bing Shuai; Adrian Bates; M MORENO; A. K. Shetty

Early Curcumin Treatment After Exposure to Blast Shock Waves Prevents Long-term Cognitive and Memory Impairments and Maintains Higher Levels of Hippocampal Neurogenesis.

Raghavendra Upadhya, UPADHYA D, Bharathi Hattiangady, A ROBBINS, Maheedhar Kodali, Bing Shuai, Adrian Bates, M MORENO, A. K. Shetty

Manipal Center for Biotherapeutics Research

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Abstract

Exposure to blast shock waves (SWs) underlies a significant fraction of combat related mild traumatic brain injury incurred by Operation Iraqi Freedom and Operation Enduring Freedom Veterans. Mild traumatic brain injury resulting from the exposure to blast SWs leads to cognitive, and memory dysfunction over variable time-periods depending upon the severity of the exposure. These impairments are likely linked to evolving neuroinflammation and decreased hippocampal neurogenesis. We investigated whether 7 days of curcumin treatment starting 2 hours after an exposure to SWs of a single blast can block hippocampus-dependent cognitive and memory impairments and restrain adverse alterations in the hippocampus, at an extended time-point after exposure.

Original language	English
Title of host publication	Early curcumin treatment after exposure to blast shock waves prevents long-term cognitive and memory impairments and maintains higher levels of hippocampal neurogenesis
Publisher	Society for Neuroscience
Publication status	Published - 15-11-2017

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Upadhya, R., D, UPADHYA., Hattiangady, B., ROBBINS, A., Kodali, M., Shuai, B., Bates, A., MORENO, M., & Shetty, A. K. (2017). Early Curcumin Treatment After Exposure to Blast Shock Waves Prevents Long-term Cognitive and Memory Impairments and Maintains Higher Levels of Hippocampal Neurogenesis. In Early curcumin treatment after exposure to blast shock waves prevents long-term cognitive and memory impairments and maintains higher levels of hippocampal neurogenesis Society for Neuroscience.

Upadhya, Raghavendra ; D, UPADHYA ; Hattiangady, Bharathi et al. / Early Curcumin Treatment After Exposure to Blast Shock Waves Prevents Long-term Cognitive and Memory Impairments and Maintains Higher Levels of Hippocampal Neurogenesis. Early curcumin treatment after exposure to blast shock waves prevents long-term cognitive and memory impairments and maintains higher levels of hippocampal neurogenesis. Society for Neuroscience, 2017.

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title = "Early Curcumin Treatment After Exposure to Blast Shock Waves Prevents Long-term Cognitive and Memory Impairments and Maintains Higher Levels of Hippocampal Neurogenesis.",

abstract = "Exposure to blast shock waves (SWs) underlies a significant fraction of combat related mild traumatic brain injury incurred by Operation Iraqi Freedom and Operation Enduring Freedom Veterans. Mild traumatic brain injury resulting from the exposure to blast SWs leads to cognitive, and memory dysfunction over variable time-periods depending upon the severity of the exposure. These impairments are likely linked to evolving neuroinflammation and decreased hippocampal neurogenesis. We investigated whether 7 days of curcumin treatment starting 2 hours after an exposure to SWs of a single blast can block hippocampus-dependent cognitive and memory impairments and restrain adverse alterations in the hippocampus, at an extended time-point after exposure.",

author = "Raghavendra Upadhya and UPADHYA D and Bharathi Hattiangady and A ROBBINS and Maheedhar Kodali and Bing Shuai and Adrian Bates and M MORENO and Shetty, {A. K.}",

year = "2017",

month = nov,

day = "15",

language = "English",

booktitle = "Early curcumin treatment after exposure to blast shock waves prevents long-term cognitive and memory impairments and maintains higher levels of hippocampal neurogenesis",

publisher = "Society for Neuroscience",

address = "United States",

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Upadhya, R, D, UPADHYA, Hattiangady, B, ROBBINS, A, Kodali, M, Shuai, B, Bates, A, MORENO, M & Shetty, AK 2017, Early Curcumin Treatment After Exposure to Blast Shock Waves Prevents Long-term Cognitive and Memory Impairments and Maintains Higher Levels of Hippocampal Neurogenesis. in Early curcumin treatment after exposure to blast shock waves prevents long-term cognitive and memory impairments and maintains higher levels of hippocampal neurogenesis. Society for Neuroscience.

Early Curcumin Treatment After Exposure to Blast Shock Waves Prevents Long-term Cognitive and Memory Impairments and Maintains Higher Levels of Hippocampal Neurogenesis. / Upadhya, Raghavendra; D, UPADHYA; Hattiangady, Bharathi et al.
Early curcumin treatment after exposure to blast shock waves prevents long-term cognitive and memory impairments and maintains higher levels of hippocampal neurogenesis. Society for Neuroscience, 2017.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - Early Curcumin Treatment After Exposure to Blast Shock Waves Prevents Long-term Cognitive and Memory Impairments and Maintains Higher Levels of Hippocampal Neurogenesis.

AU - Upadhya, Raghavendra

AU - D, UPADHYA

AU - Hattiangady, Bharathi

AU - ROBBINS, A

AU - Kodali, Maheedhar

AU - Shuai, Bing

AU - Bates, Adrian

AU - MORENO, M

AU - Shetty, A. K.

PY - 2017/11/15

Y1 - 2017/11/15

N2 - Exposure to blast shock waves (SWs) underlies a significant fraction of combat related mild traumatic brain injury incurred by Operation Iraqi Freedom and Operation Enduring Freedom Veterans. Mild traumatic brain injury resulting from the exposure to blast SWs leads to cognitive, and memory dysfunction over variable time-periods depending upon the severity of the exposure. These impairments are likely linked to evolving neuroinflammation and decreased hippocampal neurogenesis. We investigated whether 7 days of curcumin treatment starting 2 hours after an exposure to SWs of a single blast can block hippocampus-dependent cognitive and memory impairments and restrain adverse alterations in the hippocampus, at an extended time-point after exposure.

AB - Exposure to blast shock waves (SWs) underlies a significant fraction of combat related mild traumatic brain injury incurred by Operation Iraqi Freedom and Operation Enduring Freedom Veterans. Mild traumatic brain injury resulting from the exposure to blast SWs leads to cognitive, and memory dysfunction over variable time-periods depending upon the severity of the exposure. These impairments are likely linked to evolving neuroinflammation and decreased hippocampal neurogenesis. We investigated whether 7 days of curcumin treatment starting 2 hours after an exposure to SWs of a single blast can block hippocampus-dependent cognitive and memory impairments and restrain adverse alterations in the hippocampus, at an extended time-point after exposure.

UR - https://www.abstractsonline.com/pp8/#!/4376/presentation/9297

M3 - Conference contribution

BT - Early curcumin treatment after exposure to blast shock waves prevents long-term cognitive and memory impairments and maintains higher levels of hippocampal neurogenesis

PB - Society for Neuroscience

ER -

Upadhya R, D UPADHYA, Hattiangady B, ROBBINS A, Kodali M, Shuai B et al. Early Curcumin Treatment After Exposure to Blast Shock Waves Prevents Long-term Cognitive and Memory Impairments and Maintains Higher Levels of Hippocampal Neurogenesis. In Early curcumin treatment after exposure to blast shock waves prevents long-term cognitive and memory impairments and maintains higher levels of hippocampal neurogenesis. Society for Neuroscience. 2017

Early Curcumin Treatment After Exposure to Blast Shock Waves Prevents Long-term Cognitive and Memory Impairments and Maintains Higher Levels of Hippocampal Neurogenesis.

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