Early diagnosis of tongue malignancy using laser induced fluorescence spectroscopy technique

Ajeetkumar Patil; V. K. Unnikrishnan; Ravikiran Ongole; Keerthilatha M. Pai; V. B. Kartha; Santhosh Chidangil

doi:10.1117/12.2184964

Early diagnosis of tongue malignancy using laser induced fluorescence spectroscopy technique

Ajeetkumar Patil, V. K. Unnikrishnan, Ravikiran Ongole, Keerthilatha M. Pai, V. B. Kartha, Santhosh Chidangil^*

^*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Citation (Scopus)

Abstract

Oral cancer together with pharyngeal cancer is the sixth most common malignancy reported worldwide and one with high mortality ratio among all malignancies [1]. Worldwide 450,000 new cases are estimated in 2014[2]. About 90% are a type of cancer called squamous cell carcinoma (SCC). SCC of the tongue is the most common oral malignancy accounting for approximately 40% of all oral carcinomas. One of the important factors for successful therapy of any malignancy is early diagnosis. Although considerable progress has been made in understanding the cellular and molecular mechanisms of tumorigenesis, lack of reliable diagnostic methods for early detection leading to delay in therapy is an important factor responsible for the increase in the mortality rate in various types of cancers. Spectroscopy techniques are extremely sensitive for the analysis of biochemical changes in cellular systems. These techniques can provide a valuable information on alterations that occur during the development of cancer. This is especially important in oral cancer, where "tumor detection is complicated by a tendency towards field cancerization, leading to multi-centric lesions" and "current techniques detect malignant change too late" [3], and "biopsies are not representative of the whole premalignant lesion". [4]

Original language	English
Title of host publication	Clinical and Biomedical Spectroscopy and Imaging IV
Editors	J. Quincy Brown, Volker Deckert
Publisher	SPIE
Volume	9537
ISBN (Electronic)	9781628417029
DOIs	https://doi.org/10.1117/12.2184964
Publication status	Published - 01-01-2015
Event	Clinical and Biomedical Spectroscopy and Imaging IV - Munich, Germany Duration: 22-06-2015 → 24-06-2015

Publication series

Name	Progress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume	9537
ISSN (Print)	1605-7422

Conference

Conference	Clinical and Biomedical Spectroscopy and Imaging IV
Country/Territory	Germany
City	Munich
Period	22-06-15 → 24-06-15

All Science Journal Classification (ASJC) codes

Atomic and Molecular Physics, and Optics
Electronic, Optical and Magnetic Materials
Biomaterials
Radiology Nuclear Medicine and imaging

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1117/12.2184964

Cite this

Patil, A., Unnikrishnan, V. K., Ongole, R., Pai, K. M., Kartha, V. B., & Chidangil, S. (2015). Early diagnosis of tongue malignancy using laser induced fluorescence spectroscopy technique. In J. Q. Brown, & V. Deckert (Eds.), Clinical and Biomedical Spectroscopy and Imaging IV (Vol. 9537). Article 95370J (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9537). SPIE. https://doi.org/10.1117/12.2184964

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title = "Early diagnosis of tongue malignancy using laser induced fluorescence spectroscopy technique",

abstract = "Oral cancer together with pharyngeal cancer is the sixth most common malignancy reported worldwide and one with high mortality ratio among all malignancies [1]. Worldwide 450,000 new cases are estimated in 2014[2]. About 90% are a type of cancer called squamous cell carcinoma (SCC). SCC of the tongue is the most common oral malignancy accounting for approximately 40% of all oral carcinomas. One of the important factors for successful therapy of any malignancy is early diagnosis. Although considerable progress has been made in understanding the cellular and molecular mechanisms of tumorigenesis, lack of reliable diagnostic methods for early detection leading to delay in therapy is an important factor responsible for the increase in the mortality rate in various types of cancers. Spectroscopy techniques are extremely sensitive for the analysis of biochemical changes in cellular systems. These techniques can provide a valuable information on alterations that occur during the development of cancer. This is especially important in oral cancer, where {"}tumor detection is complicated by a tendency towards field cancerization, leading to multi-centric lesions{"} and {"}current techniques detect malignant change too late{"} [3], and {"}biopsies are not representative of the whole premalignant lesion{"}. [4]",

author = "Ajeetkumar Patil and Unnikrishnan, {V. K.} and Ravikiran Ongole and Pai, {Keerthilatha M.} and Kartha, {V. B.} and Santhosh Chidangil",

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doi = "10.1117/12.2184964",

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Patil, A , Unnikrishnan, VK , Ongole, R , Pai, KM, Kartha, VB & Chidangil, S 2015, Early diagnosis of tongue malignancy using laser induced fluorescence spectroscopy technique. in JQ Brown & V Deckert (eds), Clinical and Biomedical Spectroscopy and Imaging IV. vol. 9537, 95370J, Progress in Biomedical Optics and Imaging - Proceedings of SPIE, vol. 9537, SPIE, Clinical and Biomedical Spectroscopy and Imaging IV, Munich, Germany, 22-06-15. https://doi.org/10.1117/12.2184964

Early diagnosis of tongue malignancy using laser induced fluorescence spectroscopy technique. / Patil, Ajeetkumar ; Unnikrishnan, V. K.; Ongole, Ravikiran et al.
Clinical and Biomedical Spectroscopy and Imaging IV. ed. / J. Quincy Brown; Volker Deckert. Vol. 9537 SPIE, 2015. 95370J (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 9537).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

TY - GEN

T1 - Early diagnosis of tongue malignancy using laser induced fluorescence spectroscopy technique

AU - Patil, Ajeetkumar

AU - Unnikrishnan, V. K.

AU - Ongole, Ravikiran

AU - Pai, Keerthilatha M.

AU - Kartha, V. B.

AU - Chidangil, Santhosh

PY - 2015/1/1

Y1 - 2015/1/1

N2 - Oral cancer together with pharyngeal cancer is the sixth most common malignancy reported worldwide and one with high mortality ratio among all malignancies [1]. Worldwide 450,000 new cases are estimated in 2014[2]. About 90% are a type of cancer called squamous cell carcinoma (SCC). SCC of the tongue is the most common oral malignancy accounting for approximately 40% of all oral carcinomas. One of the important factors for successful therapy of any malignancy is early diagnosis. Although considerable progress has been made in understanding the cellular and molecular mechanisms of tumorigenesis, lack of reliable diagnostic methods for early detection leading to delay in therapy is an important factor responsible for the increase in the mortality rate in various types of cancers. Spectroscopy techniques are extremely sensitive for the analysis of biochemical changes in cellular systems. These techniques can provide a valuable information on alterations that occur during the development of cancer. This is especially important in oral cancer, where "tumor detection is complicated by a tendency towards field cancerization, leading to multi-centric lesions" and "current techniques detect malignant change too late" [3], and "biopsies are not representative of the whole premalignant lesion". [4]

AB - Oral cancer together with pharyngeal cancer is the sixth most common malignancy reported worldwide and one with high mortality ratio among all malignancies [1]. Worldwide 450,000 new cases are estimated in 2014[2]. About 90% are a type of cancer called squamous cell carcinoma (SCC). SCC of the tongue is the most common oral malignancy accounting for approximately 40% of all oral carcinomas. One of the important factors for successful therapy of any malignancy is early diagnosis. Although considerable progress has been made in understanding the cellular and molecular mechanisms of tumorigenesis, lack of reliable diagnostic methods for early detection leading to delay in therapy is an important factor responsible for the increase in the mortality rate in various types of cancers. Spectroscopy techniques are extremely sensitive for the analysis of biochemical changes in cellular systems. These techniques can provide a valuable information on alterations that occur during the development of cancer. This is especially important in oral cancer, where "tumor detection is complicated by a tendency towards field cancerization, leading to multi-centric lesions" and "current techniques detect malignant change too late" [3], and "biopsies are not representative of the whole premalignant lesion". [4]

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M3 - Conference contribution

AN - SCOPUS:84939857639

VL - 9537

T3 - Progress in Biomedical Optics and Imaging - Proceedings of SPIE

BT - Clinical and Biomedical Spectroscopy and Imaging IV

A2 - Brown, J. Quincy

A2 - Deckert, Volker

PB - SPIE

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Y2 - 22 June 2015 through 24 June 2015

ER -

Early diagnosis of tongue malignancy using laser induced fluorescence spectroscopy technique

Abstract

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