TY - JOUR
T1 - Educational and Socioeconomic Correlates of Stroke Risk Behaviors
T2 - Findings from the SPRINT INDIA Trial
AU - Verma, Shweta Jain
AU - Kaur, Gurnoor
AU - Devi, Arya
AU - Arora, Deepti
AU - Dhasan, Aneesh
AU - Sylaja, P. N.
AU - Khurana, Dheeraj
AU - Pamidimukkala, Vijaya
AU - Ray, Biman Kanti
AU - Nambiar, Vivek
AU - Aaron, Sanjith
AU - Mittal, Gaurav
AU - Nagarjunakonda, Sundarachary
AU - Pai, Aparna R.
AU - Gorthi, Sankar Prasad
AU - Kumaravelu, Somasundaram
AU - Reddy, Yerasu Muralidhar
AU - Narayan, Sunil
AU - Borah, Nomal Chandra
AU - Das, Rupjyoti
AU - Kulkarni, Girish Baburao
AU - Huded, Vikram
AU - Mathew, Thomas
AU - Srivastava, MV Padma
AU - Bhatia, Rohit
AU - Ojha, Pawan Kumar
AU - Roy, Jayanta
AU - Abraham, Sherly Mary
AU - Vaishnav, Anand Girish
AU - Sharma, Arvind
AU - Jabeen, Sheikh
AU - Pathak, Abhishek
AU - Bhoi, Sanjeev Kumar
AU - Sharma, Sudhir
AU - Sulena, Sulena
AU - Saroja, Aralikatte Onkarappa
AU - Ramrakhiani, Neetu
AU - Kempegowda, Madhusudhan Byadarahalli
AU - Kate, Mahesh
AU - George, Tina
AU - Sebastian, Ivy
AU - Sharma, Meenakshi
AU - Dhaliwal, Rupinder
AU - Huilgol, Rahul
AU - Pandian, Jeyaraj D.
N1 - Publisher Copyright:
© 2025 Annals of Indian Academy of Neurology.
PY - 2025/11/1
Y1 - 2025/11/1
N2 - Background and Objectives: Secondary Prevention by Structured Semi-Interactive Stroke Prevention Package in India (SPRINT INDIA) trial was a randomized control trial that enrolled 4298 stroke patients and administered educational interventions at 31 centers across India, with the aim to reduce recurrent stroke through increased stroke knowledge. This SPRINT INDIA trial post hoc study aims to investigate the incidence of recurrent stroke, high-risk transient ischemic attack (TIA), acute coronary syndrome (ACS), death, and lifestyle behavioral factors at 1 year. In addition, it examines the relationship between patients' baseline characteristics and education levels, risk factors, and outcomes and performs subgroup analysis within the intervention and control groups. Methods: Participants were randomly assigned (1:1) to either intervention or control group through computer-based randomization on web. Intervention included stroke prevention Short Message Service messages, short-duration videos, and printed workbooks. Baseline assessments captured demographic and educational data, classifying patients into three categories: no schooling, less than high school, and high school or above. Primary outcome was a composite of recurrent stroke, high-risk TIA, ACS, and mortality at 1 year. Chi-square tests and analysis of variance were used to evaluate educational disparities across various variables. Results: The intervention did not reduce primary outcomes at 1 year among patients with different educational levels. Higher educational group was associated with enhanced medication adherence (94.3% vs 85.4%; P < 0.001), increased physical activity (5497.91 ± 4117.7 vs 6169.91±4828.8; P < 0.001), lower triglyceride levels, and decreased engagement in behavioral risk factors like alcohol intake (5.1% vs 6.8%; P = 0.013) and tobacco use (smoked and chewed) (4% vs 7.9%; P < 0.001 and 5.8% vs 11.6%; P = 0.020). Conclusions: Personalized secondary stroke prevention, tailored to educational levels, is crucial for effective stroke management.
AB - Background and Objectives: Secondary Prevention by Structured Semi-Interactive Stroke Prevention Package in India (SPRINT INDIA) trial was a randomized control trial that enrolled 4298 stroke patients and administered educational interventions at 31 centers across India, with the aim to reduce recurrent stroke through increased stroke knowledge. This SPRINT INDIA trial post hoc study aims to investigate the incidence of recurrent stroke, high-risk transient ischemic attack (TIA), acute coronary syndrome (ACS), death, and lifestyle behavioral factors at 1 year. In addition, it examines the relationship between patients' baseline characteristics and education levels, risk factors, and outcomes and performs subgroup analysis within the intervention and control groups. Methods: Participants were randomly assigned (1:1) to either intervention or control group through computer-based randomization on web. Intervention included stroke prevention Short Message Service messages, short-duration videos, and printed workbooks. Baseline assessments captured demographic and educational data, classifying patients into three categories: no schooling, less than high school, and high school or above. Primary outcome was a composite of recurrent stroke, high-risk TIA, ACS, and mortality at 1 year. Chi-square tests and analysis of variance were used to evaluate educational disparities across various variables. Results: The intervention did not reduce primary outcomes at 1 year among patients with different educational levels. Higher educational group was associated with enhanced medication adherence (94.3% vs 85.4%; P < 0.001), increased physical activity (5497.91 ± 4117.7 vs 6169.91±4828.8; P < 0.001), lower triglyceride levels, and decreased engagement in behavioral risk factors like alcohol intake (5.1% vs 6.8%; P = 0.013) and tobacco use (smoked and chewed) (4% vs 7.9%; P < 0.001 and 5.8% vs 11.6%; P = 0.020). Conclusions: Personalized secondary stroke prevention, tailored to educational levels, is crucial for effective stroke management.
UR - https://www.scopus.com/pages/publications/105025535282
UR - https://www.scopus.com/pages/publications/105025535282#tab=citedBy
U2 - 10.4103/aian.aian_933_24
DO - 10.4103/aian.aian_933_24
M3 - Article
AN - SCOPUS:105025535282
SN - 0972-2327
VL - 28
SP - 863
EP - 870
JO - Annals of Indian Academy of Neurology
JF - Annals of Indian Academy of Neurology
IS - 6
ER -
SDG 3 Good Health and Well-being