TY - JOUR
T1 - Effect of Aerva lanata on cisplatin and gentamicin models of acute renal failure
AU - Shirwaikar, A.
AU - Issac, D.
AU - Malini, S.
N1 - Cited By :69
Export Date: 10 November 2017
CODEN: JOETD
Correspondence Address: Shirwaikar, A.; Department of Pharmacognosy, College of Pharmaceutical Sciences, Manipal 576119, Karnataka, India; email: [email protected]
Chemicals/CAS: alcohol, 64-17-5; cisplatin, 15663-27-1, 26035-31-4, 96081-74-2; gentamicin, 1392-48-9, 1403-66-3, 1405-41-0
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PY - 2004
Y1 - 2004
N2 - The ethanol extract of the entire plant of Aerva lanata was studied for its nephroprotective activity in cisplatin- and gentamicin-induced acute renal injury in albino rats of either sex. In the curative regimen, the extract at dose levels of 75, 150 and 300mg/kg showed dose-dependent reduction in the elevated blood urea and serum creatinine and normalized the histopathological changes in the curative regimen . In the gentamicin model the rats in the preventive regimen also showed good response to the ethanol extract at 300mg/kg. The findings suggest that the ethanol extract of Aerva lanata possesses marked nephroprotective activity with minimal toxicity and could offer a promising role in the treatment of acute renal injury caused by nephrotoxins like cisplatin and gentamicin. © 2003 Elsevier Ireland Ltd. All rights reserved.
AB - The ethanol extract of the entire plant of Aerva lanata was studied for its nephroprotective activity in cisplatin- and gentamicin-induced acute renal injury in albino rats of either sex. In the curative regimen, the extract at dose levels of 75, 150 and 300mg/kg showed dose-dependent reduction in the elevated blood urea and serum creatinine and normalized the histopathological changes in the curative regimen . In the gentamicin model the rats in the preventive regimen also showed good response to the ethanol extract at 300mg/kg. The findings suggest that the ethanol extract of Aerva lanata possesses marked nephroprotective activity with minimal toxicity and could offer a promising role in the treatment of acute renal injury caused by nephrotoxins like cisplatin and gentamicin. © 2003 Elsevier Ireland Ltd. All rights reserved.
U2 - 10.1016/j.jep.2003.09.033
DO - 10.1016/j.jep.2003.09.033
M3 - Article
SN - 0378-8741
VL - 90
SP - 81
EP - 86
JO - Journal of Ethnopharmacology
JF - Journal of Ethnopharmacology
IS - 1
ER -