@article{994376ef1abf4ae89f07dd16b5ea8039,
title = "Effect of aqueous bark extract of Garuga pinnata Roxb. in streptozotocin-nicotinamide induced type-II diabetes mellitus",
abstract = "A study was undertaken to evaluate the antihyperglycemic activity of aqueous extract of bark of Garuga pinnata Roxb. (Burseraceae). The various parameters studied included fasting blood sugar levels, serum lipid levels, liver glycogen content, serum insulin level and glycated hemoglobin in diabetic and normal rats. Streptozotocin-nicotinamide was used to induce type-II diabetes mellitus. Treatment with the extract at two dose levels showed a significant increase in the liver glycogen and serum insulin level and a significant decrease in fasting blood glucose and glycated hemoglobin levels. The total cholesterol and serum triglycerides levels were also significantly reduced and the HDL cholesterol levels were significantly increased upon treatment with the extract thus proving the potent antidiabetic property of the plant. {\textcopyright} 2006 Elsevier Ireland Ltd. All rights reserved.",
author = "A. Shirwaikar and K. Rajendran and R. Barik",
note = "Cited By :119 Export Date: 10 November 2017 CODEN: JOETD Correspondence Address: Shirwaikar, A.; Department of Pharmacognosy, Manipal College of Pharmaceutical Sciences, Manipal, Karnataka, India; email: annieshirwaikar@yahoo.com Chemicals/CAS: glucose, 50-99-7, 84778-64-3; glycosylated hemoglobin, 9062-63-9; nicotinamide, 11032-50-1, 98-92-0; streptozocin, 18883-66-4; Blood Glucose; Glycogen, 9005-79-2; Hemoglobin A, Glycosylated; Hypoglycemic Agents; Lipids; Plant Extracts; Water, 7732-18-5 References: American Diabetes Association, Standards of medical care for patients with diabetes mellitus (1998) Diabetes Care, 21, pp. 23-31; Bonner-Weir, S., Morphological evidence of pancreatic polarity of beta cells within islets of langerhans (1988) Diabetes, 37, pp. 616-621; Chatterjea, M.N., Shinde, R., (2002) Text Book of Medical Biochemistry, , Jaypee Brothers Medical Publishers, New Delhi p. 317; Ghosh, M.N., (1984) Fundamentals of Experimental Pharmacology, , Scientific Book Agency, Calcutta p. 153; Hall, P.M., Cook, J.G.H., Sheldon, J., Rutherford, S.M., Gould, B.J., Glycosylated hemoglobin and glycosylated plasma proteins in the diagnosis of diabetes mellitus and impaired glucose tolerance (1984) Diabetes Care, 7, pp. 391-393; Harborne, J.B., (1998) Phytochemical Methods, , Chapman & Hall, London p. 60; Jain, S.K., Sinha, B.K., Gupta, R.C., (1991) Notable Plants in Ethnomedicine of India, , Deep Publications p. 121; Kavalali, G., Tuncel, H., Goksel, S., Hatemi, M.H., Hypoglycemic activity of Urtica pilulifera in streptozotocin-diabetic rats (2002) Journal of Ethnopharmacology, 84, pp. 241-245; Kirtikar, K.R., Basu, B.D., (1991) Indian Medicinal Plants, 2nd ed., vol. I, , Periodical Experts Book Agency pp. 524-525; Kokate, C.K., (1994) Practical Pharmacognosy, , Vallabh Prakashan, New Delhi p. 107; Latner, A., (1958) Clinical Biochemistry, , Saunders, Philadelphia p. 48; Maiti, R., Jana, D., Das, U.K., Ghosh, D., Antidiabetic effect of aqueous extract of seed of Tamarindus indica in streptozotocin-induced diabetic rats (2004) Journal of Ethnopharmacology, 92, pp. 85-91; Nadkarni, A.K., (1954) Indian Material Medica, , Hindustan Publishing Co. p. 570; Nicholas, V., The determination of glycogen in liver and muscle by use of anthrone reagent (1956) Indian Journal of Biological Chemistry, 220, p. 583; Pellegrino, M., Christophe, B., Rene, G., Michele, R., Michele, M., Dominique, H.B., Michela, N., Gerard, R., Development of a new model of type II diabetes in adult rats administered with streptozotocin and nicotinamide (1998) Diabetes, 47, p. 224; Biesbroeck, R.C., Albers, J.J., Wahl, P.W., Weinberg, C.R., Bassett, M.L., Biermann, E.L., Abnormal composition of high-density lipoproteins in non-insulin-dependent diabetics (1982) Diabetes, 31, pp. 126-131; Shirwaikar, A., Rajendran, K., Dinesh Kumar, C., Bodla, R., Antidiabetic activity of aqueous leaf extract of Annona squamosa in streptozotocin-nicotinamide type 2 diabetic rats (2004) Journal of Ethnopharmacology, 91, pp. 171-175; Shirwaikar, A., Rajendran, K., Punitha, I.S.R., Antidiabetic activity of alcoholic stem extract of Coscinium fenestratum in streptozotocin-nicotinamide type 2 diabetic rats (2005) Journal of Ethnopharmacology, 97, pp. 369-374; Swanston-Flat, S.K., Day, C., Bailey, C.J., Flatt, P.R., Traditional plant treatment for diabetes: studies in normal and streptozotocin diabetic mice (1990) Diabetologia, 33, pp. 462-464; The Wealth of India, Garuga (1950) A Dictionary of Indian Raw Materials and Industrial Products, , CSIR, New Delhi, India p. 117; Turner, M.A., (1965) Screening Methods in Pharmacology, , Academic Press, New York p. 26; Whitton, P.D., Hems, D.A., Glycogen synthesis in perfused liver of streptozotocin diabetic rats (1975) Biochemical Journal, 150, p. 153; Wongsinkongman, P., Brossi, A., Wang, H.K., Bastow, K.F., Lee, K.H., Antitumour agents. Part 209. Pheophorbide a derivatives as photo independent cytotoxic agents (2002) Bioorganic and Medicinal Chemistry, 10 (3), pp. 583-591",
year = "2006",
doi = "10.1016/j.jep.2006.03.012",
language = "English",
volume = "107",
pages = "285--290",
journal = "Journal of Ethnopharmacology",
issn = "0378-8741",
publisher = "Elsevier Ireland Ltd",
number = "2",
}
