TY - JOUR
T1 - Effect of aqueous extract of andrographis paniculata on leukocyte count in different wound models of wistar rats
AU - Durgoji Rao, Manjula Shimoga
AU - Prasanna Kumar, Sucheta
AU - Krishnanada Rao, Vasanthalaxmi
N1 - Publisher Copyright:
© 2020, Indian Association of Biomedical Scientists. All rights reserved.
PY - 2020/1/1
Y1 - 2020/1/1
N2 - Introduction and Aim: Andrographis paniculata Nees (Ap), well-known medicinal plant in India, has antiinflammatory, antioxidant properties. In wound healing process, WBCs plays very important role in the inflammatory phase. As Ap has anti-inflammatory effect, the present study was designed to evaluate the effects of aqueous extract of Ap on WBCs in different wound models in Wistar albino rats. Methodology: Total leucocyte count and differential leucocyte count (DLC) were done in different wound models in Wistar rats treated with aqueous extract of leaves of Ap (400mg/kg body weight). Results: There was an increase in the total leucocyte count and lymphocyte count in rats treated with aqueous extract of Ap in all three models of wound, but it was not very significant compared to wounded rats. Conclusion: A. paniculata Nees is one of the most widely used herb in Ayurvedic formulations as it has antiinflammatory, antioxidant properties in vitro as well as in vivo systems. This could be the reason for the insignificant increase in the total leucocyte count and lymphocyte count in Ap treated rats compared to wounded rats.
AB - Introduction and Aim: Andrographis paniculata Nees (Ap), well-known medicinal plant in India, has antiinflammatory, antioxidant properties. In wound healing process, WBCs plays very important role in the inflammatory phase. As Ap has anti-inflammatory effect, the present study was designed to evaluate the effects of aqueous extract of Ap on WBCs in different wound models in Wistar albino rats. Methodology: Total leucocyte count and differential leucocyte count (DLC) were done in different wound models in Wistar rats treated with aqueous extract of leaves of Ap (400mg/kg body weight). Results: There was an increase in the total leucocyte count and lymphocyte count in rats treated with aqueous extract of Ap in all three models of wound, but it was not very significant compared to wounded rats. Conclusion: A. paniculata Nees is one of the most widely used herb in Ayurvedic formulations as it has antiinflammatory, antioxidant properties in vitro as well as in vivo systems. This could be the reason for the insignificant increase in the total leucocyte count and lymphocyte count in Ap treated rats compared to wounded rats.
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U2 - 10.51248/.v40i1.107
DO - 10.51248/.v40i1.107
M3 - Article
AN - SCOPUS:85098518306
SN - 0970-2067
VL - 40
SP - 72
EP - 75
JO - Biomedicine
JF - Biomedicine
IS - 1
ER -