Effect of Berberis aristata on type I and II diabetes mellitus models in albino rats

Naresh Kumar Rameshwar, Rekha Raghuveer Shenoy, Arun Theerthahalli Sudheendra, Chamalamudi Mallikarjuna Rao

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Aim: To explore the anti-diabetic potential of Berberis aristata in rodents. Materials and methods: Albino rats of Wistar strain were treated with the aqueous and ethanolic extracts of BA. Blood glucose level, liver glycogen level, thio- barbituric acid reactive substance (TBARS) and protein in pancreas were estimated. Results: Both the extracts of BA produced significant hypoglycemic effect in Streptozotocin (type I) and Streptozotocin- Nicotinamide (type II) induced diabetic models. Significant (p< 0.05) reversal in liver glycogen depletion was observed. The oxidative stress caused by streptozotocin-induced diabetes was not significantly altered by the extracts. The extracts showed more hypoglycemic effect than glibenclamide in the Streptozotocin (STZ) - Nicotinamide induced diabetic model. Conclusion: Berberis aristata can be a promising candidate for the treatment of type II diabetes mellitus.

Original languageEnglish
Pages (from-to)89-96
Number of pages8
Publication statusPublished - 2009

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Drug Discovery


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