Effect of chronic unpredictable stressors on some selected lipid parameters and biochemical parameters in Wistar rats

A. K. Nayanatara, H. S. Nagaraja, C. Ramaswamy, K. Bhagyalakshmi, Bhat M. Ramesh, Gowda K.M. Damodara, S. Mantur Venkappa

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22 Citations (Scopus)


Objective: Exposure to stressful situations is among the most common human experiences. Chronic stress exposure has detrimental effect on several cell functions. In this study, we investigated the changes in selected biochemical and lipid parameters following exposure to chronic unpredictable stressors for 10 days. Methods: Wistar strain adult albino rats were divided into two group as non stressed group (n = 8) and stressed group (n = 8). The stressed groups were exposed to 10 days of chronic unpredictable stress (CUS). At the end of the 10th day the animals were anaesthetized and blood samples were collected through cardiac puncture. The blood samples of both the groups were analyzed for selected biochemical and lipid parameters. The results were analyzed statistically by using student't test. P < 0.05 was considered as significant. Results: All the biochemical (serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT), blood sugar, tissue malondialdehyde (MDA) and serum lipid profile (cholesterol, serum tniglyceride (TG), low-density hpoproteins (LDL) were significantly increased in the stressed group when compared to the non stressed group. The serum high-density lipoproteins (HDL) level did not show any statistically significant changes. The weight of the adrenal gland also showed a significant increase in the stressed group. Conclusion: The present data indicate that cumulative effect of repeated chronic unpredictable stressors on a daily basis for a period of 10 days increases the biochemical and lipid parameters.

Original languageEnglish
Pages (from-to)92-97
Number of pages6
JournalJournal of Chinese Clinical Medicine
Issue number2
Publication statusPublished - 08-06-2009

All Science Journal Classification (ASJC) codes

  • Medicine(all)


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