Effect of crystallinity on absorption and excretion patterns of ibuprofen, tinidazole and lorazepam

Various physical forms of Ibuprofen, Tinidazole and Lorazepam were prepared. Different crystal forms of these drugs were characterized with the help of Differential Scanning Calorimetry X-ray diffrection patterns, I.R. spectra and micro photographs of samples. The dissolution and diffusion rates of physical forms were determined. The absorption pattern of drug by insitu rat intestine was also studied using Doluisio technique. After oral administration cumulative amount of drug excreted in urine was determined.