Effect of grandmal seizures on oxidative stress and antioxidants in epileptics

T. G. Sathisha, B. V. Shetty, G. M. Rao, K. Sudha

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


Plasma lipid peroxidation, antioxidants viz, glutathione and uric acid have been determined by spectrophotometric method in 25 healthy subjects and 25 epileptics after an episode of generalized seizure. The study showed significant increase in plasma lipid peroxidation and uric acid in epileptics compared to normals. However, blood glutathione levels decreased significantly in these patients compared to controls. It can be concluded that these patients are under oxidative stress which points to a possible involvement of free radicals in epilepsy.

Original languageEnglish
Pages (from-to)167-169
Number of pages3
JournalBiomedical Research
Issue number3
Publication statusPublished - 01-09-2007

All Science Journal Classification (ASJC) codes

  • General Biochemistry,Genetics and Molecular Biology


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