TY - JOUR
T1 - Effect of helicteres isora root extract on gluconeogenic and glycolytic enzymes in streptozotocin-induced diabetic rats
AU - Sharma, A.
AU - Vijayakumar, M.
AU - Verma, A.R.
AU - Unnikrishnan, M.K.
AU - Singh, M.
AU - Rao, Ch.V.
N1 - Export Date: 10 November 2017
CODEN: BOMEF
Correspondence Address: Sharma, A.; Pharmacognosy and Ethnopharmacology Division, National Botanical Research Institute (CSIR), Rana Pratap Marg, Lucknow-226 001, India; email: [email protected]
Chemicals/CAS: fructose bisphosphatase, 9001-52-9; fructose bisphosphate aldolase, 9024-52-6; glucose 6 phosphatase, 9001-39-2; glucose 6 phosphate isomerase, 9001-41-6; glucose, 50-99-7, 84778-64-3; hexokinase, 9001-51-8; insulin, 9004-10-8; streptozocin, 18883-66-4
References: Zimmet, P.Z., Diabetes epidemiology as a tool to trigger diabetes research and care (1999) Diabetologia, 42, pp. 499-518; Rates, S.M., Plant as a source of Drug (2001) Toxicon, 39, pp. 603-613; Bailey, C.J., Day, C., Traditional plant medicines as treatment for diabetes (1989) Diab Care, 12, pp. 553-564; Chopra, R.N., Nayar, S.L., Chopra, I.C., (1956) Glossary of Indian medicinal plants, p. 131. , New Delhi: CSIR publicatios; Pohocha, N., Grampurohit, N.D., Antispasmodic activity of the fruits of Helicteres isora Linn (2001) Phytother Res, 15, pp. 49-52; Kumar, G., Sharmila Banu, G., Murugesan, A.G., Rajasekara, P.M., Effect of Helicteres isora bark extract on blood glucose and hepatic enzymes in experimental diabetes (2006) Pharmazie, 61, pp. 353-355; Kumar, G., Sharmila Banu, G., Murugesan, A.G., Rajasekara, P.M., Hypoglycaemic effect of Helicteres isora bark extract in rats (2006) J Ethnopharmacol, 107, pp. 304-307; Branstrup, N., Krik, J.E., Bruni, C., The hexokinase and phosphoglucoisomerase activities of aorta and pulmonary artery tissue in individuals of various ages (1957) J Gerontol, 12, pp. 166-171; Horrocks, J.E., Ward, J., Kind, J., A routine method for the determination of phosphoglucoisomerase activity in body fluid (1963) J Clin Pathol, 16, pp. 248-251; King, J., The hydrolases-acid and alkaline phosphatase (1965) Practical clinical enzymology, pp. 83-93. , Van D, editor. London: London: Norstand company Ltd; King J. The dehydrogenase or oxido reductaselactate dehydrogenase. In: Practical clinical enzymology. Van D, editor. London: Norstand co. Ltd. 1965; 83-93; Gancedo, J.M., Gancedo, C., Fructose-1, 6-diphosphatase, phosphofructokinase and glucose-6-phosphate dehydrogenase. Prooc Sosc (1971) Exp Biol Med, 106, pp. 607-609; Bhavapriya, V., Govidasamy, S., Biochemical studies on the hypoglycemic effect Aegle marmelos (Linn) correa ex. RoxB, in streptozotocin induced diabetic rats (2000) Ind Drugs, 37, pp. 474-477; Ebrahim, A.S., Babakrishnan, K., Sakthisekaran, D., Perchloroethylene-induced alterations in glucose metabolism and their prevention by 2 deoxy-D-glucose and vitamin E in mice (1996) J Appl Toxicol, 16, pp. 339-348; Arathi, G., Sachdanandam, Therapeutic effect of Semecarpus and Cardium Linn, nut milk extract on carbohydrate metabolizing and mitochondrial TCA cycle and respiratory chain enzymes in mammary carcinoma rats (2003) J Pharmol, 55, pp. 1283-1290; Murray, R.L., Granner, D.K., Mayes, P.A., Rodwell, V.W., Harper's Biochemistry (2000) Singapore: Appleton and Lange Stanford Connecticut-Mc Graw Hill Comp, pp. 170-173. , 25th ed; Prakasam S, Sethupathy and Pugalendi KV. Antihyperglycaemic effect of Caseariaesculenta root extracts in streptozotocin-induced diabetic rats. Pharmazie 2002; 57: 758UR - https://www.scopus.com/inward/record.uri?eid=2-s2.0-58349111547&partnerID=40&md5=927bf735ecd1476acfc1bb743654df01
PY - 2008
Y1 - 2008
N2 - The aqueous extract of the bark showed a significant hypoglycaemic effect and hepatic enzymes lowering effect. However, ability of Helicteres isora bark on gluconeogenic and glycolytic enzymes in diabetes has not been studied yet. Present investigation has been carried out to study the regulation of carbohydrate metabolic and catabolic such as hexokinase, aldolase and phosphoglucoisomerase, and gluconeogenic enzymes such as glucose-6-phosphatase and fructose -1,6-diphosphatase in liver and kidneys of normal and streptozotocin induced diabetic rats. There were a decrease in the activities of glucose-6-phosphatase, fructose-1, 6-disphosphatase, aldolase and an increase in the activity of phosphoglucoisomerase and hexokinase in tissues. Helicteres isora extract exhibited antidiabetic activity by enhancing the peripheral utilization of glucose by correcting liver and kidney glycolysis and by limiting its gluconeogenic formation similar to insulin.
AB - The aqueous extract of the bark showed a significant hypoglycaemic effect and hepatic enzymes lowering effect. However, ability of Helicteres isora bark on gluconeogenic and glycolytic enzymes in diabetes has not been studied yet. Present investigation has been carried out to study the regulation of carbohydrate metabolic and catabolic such as hexokinase, aldolase and phosphoglucoisomerase, and gluconeogenic enzymes such as glucose-6-phosphatase and fructose -1,6-diphosphatase in liver and kidneys of normal and streptozotocin induced diabetic rats. There were a decrease in the activities of glucose-6-phosphatase, fructose-1, 6-disphosphatase, aldolase and an increase in the activity of phosphoglucoisomerase and hexokinase in tissues. Helicteres isora extract exhibited antidiabetic activity by enhancing the peripheral utilization of glucose by correcting liver and kidney glycolysis and by limiting its gluconeogenic formation similar to insulin.
M3 - Article
SN - 0970-2067
VL - 28
SP - 298
EP - 301
JO - Biomedicine
JF - Biomedicine
IS - 4
ER -
SDG 3 Good Health and Well-being