TY - JOUR
T1 - Effect of limited access dressing on hydroxyproline and enzymatic antioxidant status in nonhealing chronic ulcers
AU - Honnegowda, Thittamaranahalli Muguregowda
AU - Kumar, Pramod
AU - Udupa, Padmanabha
AU - Rao, Pragna
AU - Bhandary, Siddhartha
AU - Mahato, Krishna Kumar
AU - Sharan, Anurag
AU - Mayya, Shreemathi S.
PY - 2014
Y1 - 2014
N2 - Background: Healing ability of nonhealing chronic ulcers can be assessed by estimating hydroxyproline, total protein and enzymatic antioxidants such as glutathione peroxidase (GPx), glutathione S-transferase (GST) in the granulation tissue. Materials and Method: A total of 34 patients were analysed from two groups: Limited access dressing (LAD) group (n = 17) and conventional dressing group (n = 17). Results: Patients treated with LAD that exerts combination of intermittent negative pressure and moist wound-healing had shown a significant increase in the hydroxyproline (P = 0.026), total protein (P = 0.004), GPx level (P = 0.030) and GST level (P = 0.045). Conclusion: Patients treated with LAD indicated significantly better anabolic effect on wound-healing compared to that of patients treated with conventional dressing.
AB - Background: Healing ability of nonhealing chronic ulcers can be assessed by estimating hydroxyproline, total protein and enzymatic antioxidants such as glutathione peroxidase (GPx), glutathione S-transferase (GST) in the granulation tissue. Materials and Method: A total of 34 patients were analysed from two groups: Limited access dressing (LAD) group (n = 17) and conventional dressing group (n = 17). Results: Patients treated with LAD that exerts combination of intermittent negative pressure and moist wound-healing had shown a significant increase in the hydroxyproline (P = 0.026), total protein (P = 0.004), GPx level (P = 0.030) and GST level (P = 0.045). Conclusion: Patients treated with LAD indicated significantly better anabolic effect on wound-healing compared to that of patients treated with conventional dressing.
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U2 - 10.4103/0970-0358.138952
DO - 10.4103/0970-0358.138952
M3 - Article
AN - SCOPUS:84906854467
SN - 0970-0358
VL - 47
SP - 216
EP - 220
JO - Indian Journal of Plastic Surgery
JF - Indian Journal of Plastic Surgery
IS - 2
ER -