Effect of niosome encapsulation of methotrexate, macrophage activation on tissue distribution of methotrexate and tumor size

K. S. Chandraprakash; N. Udupa; P. Uma Devi; G. K. Pillai

doi:10.3109/10717549309022767

Effect of niosome encapsulation of methotrexate, macrophage activation on tissue distribution of methotrexate and tumor size

K. S. Chandraprakash^*, N. Udupa, P. Uma Devi, G. K. Pillai

^*Corresponding author for this work

Department of Pharmacy Management, Manipal College of Pharmaceutical Sciences, Manipal

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Methotrexate was encapsulated in "niosomes" of sorbitan monostearate (Span 60) by the reverse phase evaporation technique. After i.v. infusion into mice methotrexate concentration was higher in all tissues except kidney with niosomal methotrexate than with methotrexate solution. Niosome encapsulation and macrophage activation enhanced the delivery of methotrexate to the tumor and increased its antitumor activity.

Original language	English
Pages (from-to)	133-137
Number of pages	5
Journal	Drug Delivery
Volume	1
Issue number	2
DOIs	https://doi.org/10.3109/10717549309022767
Publication status	Published - 1993

All Science Journal Classification (ASJC) codes

Pharmaceutical Science

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AU - Chandraprakash, K. S.

AU - Udupa, N.

AU - Devi, P. Uma

AU - Pillai, G. K.

PY - 1993

Y1 - 1993

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AB - Methotrexate was encapsulated in "niosomes" of sorbitan monostearate (Span 60) by the reverse phase evaporation technique. After i.v. infusion into mice methotrexate concentration was higher in all tissues except kidney with niosomal methotrexate than with methotrexate solution. Niosome encapsulation and macrophage activation enhanced the delivery of methotrexate to the tumor and increased its antitumor activity.

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Effect of niosome encapsulation of methotrexate, macrophage activation on tissue distribution of methotrexate and tumor size

Abstract

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