Effect of niosome encapsulation of methotrexate, macrophage activation on tissue distribution of methotrexate and tumor size

K. S. Chandraprakash; N. Udupa; P. Uma Devi; G. K. Pillai

doi:10.3109/10717549309022767

Effect of niosome encapsulation of methotrexate, macrophage activation on tissue distribution of methotrexate and tumor size

K. S. Chandraprakash^*
, N. Udupa
, P. Uma Devi
, G. K. Pillai

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

Methotrexate was encapsulated in "niosomes" of sorbitan monostearate (Span 60) by the reverse phase evaporation technique. After i.v. infusion into mice methotrexate concentration was higher in all tissues except kidney with niosomal methotrexate than with methotrexate solution. Niosome encapsulation and macrophage activation enhanced the delivery of methotrexate to the tumor and increased its antitumor activity.

Original language	English
Pages (from-to)	133-137
Number of pages	5
Journal	Drug Delivery
Volume	1
Issue number	2
DOIs	https://doi.org/10.3109/10717549309022767
Publication status	Published - 1993

All Science Journal Classification (ASJC) codes

Pharmaceutical Science

Access to Document

10.3109/10717549309022767

Cite this

@article{0f3efef754954582858ac5ea54f66491,

title = "Effect of niosome encapsulation of methotrexate, macrophage activation on tissue distribution of methotrexate and tumor size",

abstract = "Methotrexate was encapsulated in {"}niosomes{"} of sorbitan monostearate (Span 60) by the reverse phase evaporation technique. After i.v. infusion into mice methotrexate concentration was higher in all tissues except kidney with niosomal methotrexate than with methotrexate solution. Niosome encapsulation and macrophage activation enhanced the delivery of methotrexate to the tumor and increased its antitumor activity.",

author = "Chandraprakash, \{K. S.\} and N. Udupa and Devi, \{P. Uma\} and Pillai, \{G. K.\}",

year = "1993",

doi = "10.3109/10717549309022767",

language = "English",

volume = "1",

pages = "133--137",

journal = "Drug Delivery",

issn = "1071-7544",

publisher = "Taylor and Francis Ltd.",

number = "2",

}

TY - JOUR

T1 - Effect of niosome encapsulation of methotrexate, macrophage activation on tissue distribution of methotrexate and tumor size

AU - Chandraprakash, K. S.

AU - Udupa, N.

AU - Devi, P. Uma

AU - Pillai, G. K.

PY - 1993

Y1 - 1993

N2 - Methotrexate was encapsulated in "niosomes" of sorbitan monostearate (Span 60) by the reverse phase evaporation technique. After i.v. infusion into mice methotrexate concentration was higher in all tissues except kidney with niosomal methotrexate than with methotrexate solution. Niosome encapsulation and macrophage activation enhanced the delivery of methotrexate to the tumor and increased its antitumor activity.

AB - Methotrexate was encapsulated in "niosomes" of sorbitan monostearate (Span 60) by the reverse phase evaporation technique. After i.v. infusion into mice methotrexate concentration was higher in all tissues except kidney with niosomal methotrexate than with methotrexate solution. Niosome encapsulation and macrophage activation enhanced the delivery of methotrexate to the tumor and increased its antitumor activity.

UR - https://www.scopus.com/pages/publications/2442770763

UR - https://www.scopus.com/pages/publications/2442770763#tab=citedBy

U2 - 10.3109/10717549309022767

DO - 10.3109/10717549309022767

M3 - Article

AN - SCOPUS:2442770763

SN - 1071-7544

VL - 1

SP - 133

EP - 137

JO - Drug Delivery

JF - Drug Delivery

IS - 2

ER -

Effect of niosome encapsulation of methotrexate, macrophage activation on tissue distribution of methotrexate and tumor size

Abstract

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this