Effect of physical activity intervention in prediabetes: A systematic review with meta-analysis

Background: Prediabetes is a strong risk factor for the development of Type2 Diabetes Mellitus (T2DM). Modifcation in lifestyle plays an important role to avoid the prognosis of T2DM and its complications in future. The aim of our study was to focus on the effectiveness of physical activity (PA) intervention program on different outcome measures in individuals with prediabetes. The effort of the present review was to contribute to the existing literature by strengthening the evidence pointing toward the positive impact of physical activity in individuals with prediabetes. Methods: Studies have been identifed through database like PubMed, Scopus, and ProQuest. Randomized and nonrandomized controlled trials have been included. Nineteen articles have been selected for the qualitative analysis and 08 for meta-analysis. Results: PA intervention showed a favorable effect on improving oral glucose tolerance (Risk ratio [RR] -0.26, 95% CI -0.06 to 0.07) and fasting blood sugar (RR -0.05, 95% CI -0.14 to 0.04). It also showed the favorable effect on glycated hemoglobin (HbA1C), maximum oxygen uptake (VO2max), and body composition. Conclusion: Present review suggests that the PA promotion and participation can help to slow down the progression of disease in individuals with prediabetes and thus reduces the morbidity and mortality associated with T2DM.