TY - JOUR
T1 - Effect of propranolol and nifedipine on maximal electroshock-induced seizures in mice
T2 - Individually and in combination
AU - Raju, S. S.
AU - Gopalakrishna, H. N.
AU - Venkatadri, N.
PY - 1998/1/1
Y1 - 1998/1/1
N2 - A comparative effect of propranolol and nifedipine administered individually and in combination at graded dose levels; and that of phenytoin at 30 mg kg-1 on maximal electroshock (MES)-induced seizure in mice was investigated. Propranolol in doses of 10 mg kg-1 and 20 mg kg-1, and nifedipine in doses of 8 mg kg-1 and 16 mg kg-1 significantly modified MES activity. Propranolol (40 mg kg-1), and a combination of propranolol (20 mg kg-1) and nifedipine (8 mg kg-1), produced antiMES activity, which was comparable to that of phenytoin (30 mg kg-1). In mice treated with propranolol and nifedipine combination, the tonic flexor and tonic extensor phase ratios (F/E ratio) were significantly higher than individual drug responses. Our findings suggest that a combination of propranolol and nifedipine has either synergistic or an additive effect in controlling MES-induced seizures in mice.
AB - A comparative effect of propranolol and nifedipine administered individually and in combination at graded dose levels; and that of phenytoin at 30 mg kg-1 on maximal electroshock (MES)-induced seizure in mice was investigated. Propranolol in doses of 10 mg kg-1 and 20 mg kg-1, and nifedipine in doses of 8 mg kg-1 and 16 mg kg-1 significantly modified MES activity. Propranolol (40 mg kg-1), and a combination of propranolol (20 mg kg-1) and nifedipine (8 mg kg-1), produced antiMES activity, which was comparable to that of phenytoin (30 mg kg-1). In mice treated with propranolol and nifedipine combination, the tonic flexor and tonic extensor phase ratios (F/E ratio) were significantly higher than individual drug responses. Our findings suggest that a combination of propranolol and nifedipine has either synergistic or an additive effect in controlling MES-induced seizures in mice.
UR - http://www.scopus.com/inward/record.url?scp=0032421264&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0032421264&partnerID=8YFLogxK
U2 - 10.1006/phrs.1998.0390
DO - 10.1006/phrs.1998.0390
M3 - Article
C2 - 9990653
AN - SCOPUS:0032421264
SN - 1043-6618
VL - 38
SP - 449
EP - 452
JO - Pharmacological Research
JF - Pharmacological Research
IS - 6
ER -