Effect of tolmetin and its copper complex on wound healing

S. N. Somayaji, A. P. Jacob, K. L. Bairy

Research output: Contribution to journalArticlepeer-review

19 Citations (Scopus)


Dose matched comparison between copper complex of tolmetin (Tol-Cu) and tolmetin (Tol) was carried out in male albino rats bearing either sutured incision, dead space or excision wounds. Results showed that Tol significantly decreased tensile strength of incision and dead space wound. This effect was totally reversed by copper present in Tol-Cu. Tol-Cu shared the significant suppressant effect of Tol on granulation formation and its collagen content. Tol suppressed wound contraction and epithelialization and copper complex of Tol antagonised the suppressant effect of Tol on wound contraction and epithelialization.

Original languageEnglish
Pages (from-to)201-204
Number of pages4
JournalIndian Journal of Experimental Biology
Issue number3
Publication statusPublished - 01-01-1995
Externally publishedYes

All Science Journal Classification (ASJC) codes

  • Bioengineering


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