TY - JOUR
T1 - Effect of tribulus terrestris on learning and memory in wistar rats
AU - Prabhu, Natesh
AU - Hadigal, Sanjay
AU - Ullal Sheetal, D.
AU - Sushma, D. S.
AU - Ashok Shenoy, K.
PY - 2014/1/1
Y1 - 2014/1/1
N2 - Objectives: The present study was designed to evaluate the effect of aqueous extract of fruits of Tribulus terrestris on learning and memory in rodents. Materials and Methods: Thirty wistar rats were divided in 5 groups of 6 rats each. Baseline values for the time taken to reach reward chamber (TRC) in the Hebb William Maze and transfer latency (TL) in the T-maze were recorded on Day 1. Mean of 5 sessions was calculated for each rat. Group I was normal control, group II piracetam standard, group III, IV and V received Tribulus terrestris orally at 100mg/kg, 200mg/kg and 400mg/kg respectively for 14 days. At the end of 14 days, each rat was tested for TRC and TL and compared with the control group. Results: Group IV showed a significant decrease in TRC when compared to group I in Hebb William Maze (p<0.0001). Group IV also showed a significant decrease in TL when compared to group I in T-maze (p<0.0001). Group III showed a significant decrease in TL when compared to group I in the T-maze (p=0.035), however there was no decrease in TRC in this group. Conclusions: The aqueous extract of fruits of Tribulus terrestris showed a dose dependent beneficial effect in learning and memory models in rats, with 200mg/kg being most beneficial.
AB - Objectives: The present study was designed to evaluate the effect of aqueous extract of fruits of Tribulus terrestris on learning and memory in rodents. Materials and Methods: Thirty wistar rats were divided in 5 groups of 6 rats each. Baseline values for the time taken to reach reward chamber (TRC) in the Hebb William Maze and transfer latency (TL) in the T-maze were recorded on Day 1. Mean of 5 sessions was calculated for each rat. Group I was normal control, group II piracetam standard, group III, IV and V received Tribulus terrestris orally at 100mg/kg, 200mg/kg and 400mg/kg respectively for 14 days. At the end of 14 days, each rat was tested for TRC and TL and compared with the control group. Results: Group IV showed a significant decrease in TRC when compared to group I in Hebb William Maze (p<0.0001). Group IV also showed a significant decrease in TL when compared to group I in T-maze (p<0.0001). Group III showed a significant decrease in TL when compared to group I in the T-maze (p=0.035), however there was no decrease in TRC in this group. Conclusions: The aqueous extract of fruits of Tribulus terrestris showed a dose dependent beneficial effect in learning and memory models in rats, with 200mg/kg being most beneficial.
UR - http://www.scopus.com/inward/record.url?scp=84929171136&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84929171136&partnerID=8YFLogxK
U2 - 10.5530/pj.2014.4.10
DO - 10.5530/pj.2014.4.10
M3 - Article
AN - SCOPUS:84929171136
SN - 0975-3575
VL - 6
SP - 68
EP - 71
JO - Pharmacognosy Journal
JF - Pharmacognosy Journal
IS - 4
ER -