TY - JOUR
T1 - Effect of Wheatgrass Juice on Fertility Changes Induced by Cyclophosphamide in Male Wistar Albino Rats
AU - Kamath, Akshatha P.
AU - Patil, Navin
AU - Parida, Amrita
AU - Rao, Karthik
AU - Khan, Nadeem G.
AU - Gurung, Shanti
AU - Itagi, Afreen Begum H.
AU - Manju, V.
AU - Islam, Heraa
AU - Kapoor, Aditi
AU - Nazeer, Mohsin
AU - Hegde, Shreya
AU - Anand, Nikhilesh
N1 - Publisher Copyright:
© 2023 Biomedical & Pharmacology Journal.
PY - 2023/6
Y1 - 2023/6
N2 - In the present study, reproductive toxicity caused by cyclophosphamide on sperm parameters, biochemical parameters, histopathology and protective effect of wheatgrass juice was examined. There were total 6 groups of adult Wistar albino rats. Each group had 6 rats. After 24hrs of the last treatment, rats were sacrificed by cervical dislocation and sperm parameters like sperm count and motility, plasma malonaldehyde (MDA) levels, catalase (CAT) levels, superoxide dismutase (SOD) and glutathione (GSH) activities in testicular tissue, and testicular histopathological changes in the testicular tissue were examined. Administration of cyclophosphamide showed an increase in plasma MDA level and decrease in SOD, GSH and Catalase activity. These values were statistically significant. However, wheatgrass juice treatment along with cyclophosphamide markedly showed improvement in reducing cyclophosphamideinduced oxidative stress, and normalized sperm characteristics and testicular histopathology. Thus, in conclusion, cyclophosphamide causes fertility changes which leads to male infertility, whereas wheatgrass juice has a protective effect on reversing the testicular damage and male infertility.
AB - In the present study, reproductive toxicity caused by cyclophosphamide on sperm parameters, biochemical parameters, histopathology and protective effect of wheatgrass juice was examined. There were total 6 groups of adult Wistar albino rats. Each group had 6 rats. After 24hrs of the last treatment, rats were sacrificed by cervical dislocation and sperm parameters like sperm count and motility, plasma malonaldehyde (MDA) levels, catalase (CAT) levels, superoxide dismutase (SOD) and glutathione (GSH) activities in testicular tissue, and testicular histopathological changes in the testicular tissue were examined. Administration of cyclophosphamide showed an increase in plasma MDA level and decrease in SOD, GSH and Catalase activity. These values were statistically significant. However, wheatgrass juice treatment along with cyclophosphamide markedly showed improvement in reducing cyclophosphamideinduced oxidative stress, and normalized sperm characteristics and testicular histopathology. Thus, in conclusion, cyclophosphamide causes fertility changes which leads to male infertility, whereas wheatgrass juice has a protective effect on reversing the testicular damage and male infertility.
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U2 - 10.13005/bpj/2682
DO - 10.13005/bpj/2682
M3 - Article
AN - SCOPUS:85165687208
SN - 0974-6242
VL - 16
SP - 1011
EP - 1017
JO - Biomedical and Pharmacology Journal
JF - Biomedical and Pharmacology Journal
IS - 2
ER -