TY - JOUR
T1 - Effects of Gmelina arborea Roxb. leaves on wound healing in rats
AU - Shirwaikar, A.
AU - Ghosh, S.
AU - Rao, P.G.M.
N1 - Cited By :20
Export Date: 10 November 2017
CODEN: JNROA
Correspondence Address: Shirwaikar, A.; Department of Pharmacognosy, College of Pharmaceutical Sciences, Manipal 576 119 Dakshina, India; email: [email protected]
Chemicals/CAS: alcohol, 64-17-5; collagen, 9007-34-5; hydroxyproline, 51-35-4, 6912-67-0
References: Satyavati, G.V., Raina, M.K., Sharma, M., (1976) Medicinal Plants of India, 1, pp. 441-444. , Indian Council of Medical Research: New Delhi; Chopra, R.N., Nayar, S.L., Chopra, I.C., (1986) Glossary of Indian Medicinal Plants, p. 126. , Publication and Information Directorate, CSIR: New Delhi; Dassanayake, M.D., Fosberg, F.R., Revised Handbook to The Flora of Ceylon, 4, pp. 388-394; Agrawal, V.K., Gambhir, S.S., Wahi, A.K., (1994) Indian J. Nat. Prod., 10 (1), pp. 14-15; Harborne, J.B., (1984) Phytochemical Methods, , 2nd edn Chapman and Hall: London; Kokate, C.K., (1991) Practical Pharmacognosy, pp. 107-121. , 3rd edn. Vallabh Prakashan: India; Ehrlich, H.P., Hunt, T.K., (1969) Ann. Surg., 170, p. 203; Lee, K.H., (1968) J. Pharmacol. Sci., 57, p. 1042; Morton, J.J.P., Malone, H.H., (1972) Arch. Int. Pharmacodyn. Ther., 196, p. 117; Neuman, R.E., Logan, M.A., (1950) J. Biol. Chem., 186, p. 83
PY - 2003
Y1 - 2003
N2 - Objective: To study the effect of the alcoholic extract of the dried leaves powder of Gmelina arborea on wound healing. Materials and method: The alcoholic extract was studied at dose level of 200 mg/kg body weight using incision, excision and dead space wound models in rats. Results: Significant increase in wound contraction rate, skin breaking strength, granuloma breaking strength, hydroxyproline content and dry granuloma weight and decrease in epithelization period was observed. The prohealing actions seem to be due to increased collagen deposition as well as better alignment and maturation. Conclusion: From the results it may be concluded that the plant Gmelina arborea is endowed with significant wound healing activity, thereby justifying its use in the traditional medicine.
AB - Objective: To study the effect of the alcoholic extract of the dried leaves powder of Gmelina arborea on wound healing. Materials and method: The alcoholic extract was studied at dose level of 200 mg/kg body weight using incision, excision and dead space wound models in rats. Results: Significant increase in wound contraction rate, skin breaking strength, granuloma breaking strength, hydroxyproline content and dry granuloma weight and decrease in epithelization period was observed. The prohealing actions seem to be due to increased collagen deposition as well as better alignment and maturation. Conclusion: From the results it may be concluded that the plant Gmelina arborea is endowed with significant wound healing activity, thereby justifying its use in the traditional medicine.
M3 - Article
SN - 0972-5547
VL - 3
SP - 45
EP - 48
JO - Journal of Natural Remedies
JF - Journal of Natural Remedies
IS - 1
ER -