TY - JOUR
T1 - Effects of reinforcement of sodium alginate functionalized halloysite clay nanotubes on thermo-mechanical properties and biocompatibility of poly (vinyl alcohol) nanocomposites
AU - Kouser, Sabia
AU - Sheik, Sareen
AU - Prabhu, Ashwini
AU - Nagaraja, G. K.
AU - Prashantha, Kalappa
AU - D'souza, Josline Neetha
AU - Navada, Meghana K.
AU - Manasa, D. J.
N1 - Funding Information:
The authors would like to express their gratitude to Mangalore University for providing instrument facility (DST-PURSE) and to the VGST project by Karnataka Government for the support in our research. The author sabia kouser thanks to the Directorate of Minorities (DOM), Karnataka Government for the fellowship. Authors would like to acknowledge Dr. Saraswasti P. Masti, Investigator Principal (DST-SERB, Project No. SB/EMEQ-213/2014), Department of Chemistry, Karnataka Science College, Dharwad, 580001, Karnataka, India, for providing facilities for mechanical testing.
Publisher Copyright:
© 2021 Elsevier Ltd
PY - 2021/6
Y1 - 2021/6
N2 - In the present work sodium alginate functionalized halloysite nanotubes (HNTs) reinforced poly (vinyl alcohol) nanocomposite films were prepared by solution casting technique. Sodium alginate surface functionalizing on the HNTs through hydrogen bonding was confirmed by spectroscopic and morphological analysis. The functionalized HNTs were successfully incorporated into the PVA matrix. Further, the films were characterized by using FTIR, TGA, XRD, SEM, AFM, UTM, WCA and swelling ratio analysis. The obtained results indicated improved physico-thermal properties, and uniform distribution of nanotubes in the matrix and roughness of the surface compared with the pristine PVA films. After inclusion of functionalized nanotubes causes enhancement of tensile strength as well as young's modulus of the nanocomposite films. Water contact angle measurement was carried out to know the hydrophilic or hydrophobic nature of the films and results were correlated with swelling ratio analysis. Furthermore, the films were analyzed for in-vitro biocompatibility studies. In -vitro enzymatic degradation was carried out in PBS media and cellular behaviour studies were analyzed using NIH3T3 cell lines. The results showed enhancement in the enzymatic degradation, proliferation, adhesion activity compared to that of pristine PVA films. In extension, nanocomposite films were subjected to hemocompatibility studies using human erythrocyte. The results revealed that nanocomposite films were biocompatible and hemocompatible. The fabricated films can be used in biomedical application.
AB - In the present work sodium alginate functionalized halloysite nanotubes (HNTs) reinforced poly (vinyl alcohol) nanocomposite films were prepared by solution casting technique. Sodium alginate surface functionalizing on the HNTs through hydrogen bonding was confirmed by spectroscopic and morphological analysis. The functionalized HNTs were successfully incorporated into the PVA matrix. Further, the films were characterized by using FTIR, TGA, XRD, SEM, AFM, UTM, WCA and swelling ratio analysis. The obtained results indicated improved physico-thermal properties, and uniform distribution of nanotubes in the matrix and roughness of the surface compared with the pristine PVA films. After inclusion of functionalized nanotubes causes enhancement of tensile strength as well as young's modulus of the nanocomposite films. Water contact angle measurement was carried out to know the hydrophilic or hydrophobic nature of the films and results were correlated with swelling ratio analysis. Furthermore, the films were analyzed for in-vitro biocompatibility studies. In -vitro enzymatic degradation was carried out in PBS media and cellular behaviour studies were analyzed using NIH3T3 cell lines. The results showed enhancement in the enzymatic degradation, proliferation, adhesion activity compared to that of pristine PVA films. In extension, nanocomposite films were subjected to hemocompatibility studies using human erythrocyte. The results revealed that nanocomposite films were biocompatible and hemocompatible. The fabricated films can be used in biomedical application.
UR - https://www.scopus.com/pages/publications/85102316059
UR - https://www.scopus.com/pages/publications/85102316059#tab=citedBy
U2 - 10.1016/j.jmbbm.2021.104441
DO - 10.1016/j.jmbbm.2021.104441
M3 - Article
C2 - 33714903
AN - SCOPUS:85102316059
SN - 1751-6161
VL - 118
JO - Journal of the Mechanical Behavior of Biomedical Materials
JF - Journal of the Mechanical Behavior of Biomedical Materials
M1 - 104441
ER -