TY - JOUR
T1 - Efficacy and safety of maintenance electroconvulsive therapy (M-ECT) in treatment-resistant schizophrenia
T2 - A case series
AU - Purohith, Abhiram Narasimhan
AU - Chatorikar, Shalaka Anand
AU - Praharaj, Samir Kumar
AU - Bhandary, Rajeshkrishna Panambur
AU - Sharma, Podila Satya Venkata Narasimha
N1 - Funding Information:
None. None.
Publisher Copyright:
© 2022 Elsevier B.V.
PY - 2022/7
Y1 - 2022/7
N2 - Background: Treatment-resistant schizophrenia (TRS) is a substantial burden to patients, caregivers, and the treating team. There is a lack of robust evidence to support the efficacy of various pharmacological and non-pharmacological measures to augment clozapine in this population. When used in conjunction with clozapine or other combination antipsychotic regimens, maintenance electroconvulsive therapy (M-ECT) can be a potential therapeutic option in preventing symptom exacerbation in TRS. However, there is limited evidence supporting the role of M-ECT in TRS. Aim: To evaluate the efficacy and safety of maintenance electroconvulsive therapy in patients with TRS. Methodology: Sociodemographic details, illness characteristics, details of M-ECT procedure, adverse events, and course of the illness were evaluated using a retrospective chart review at a tertiary care psychiatry centre in south India. Scores on Clinical Global Impression-Severity (CGI-S), Social and Occupational Functioning Assessment Scale (SOFAS), and Hindi Mental Status Examination were compared before and after the course of M-ECT. Results: Seven male and three female patients received M-ECT in the last eight years (range of 22–172 sessions). There was a reduction in hospitalizations for acute exacerbation and significant improvement in the patient's overall functioning without significant adverse effects. Conclusion: Maintenance ECT can be a safe and effective treatment option for achieving symptom control in the long-term management of refractory schizophrenia. Controlled trials are needed in this area for further evidence.
AB - Background: Treatment-resistant schizophrenia (TRS) is a substantial burden to patients, caregivers, and the treating team. There is a lack of robust evidence to support the efficacy of various pharmacological and non-pharmacological measures to augment clozapine in this population. When used in conjunction with clozapine or other combination antipsychotic regimens, maintenance electroconvulsive therapy (M-ECT) can be a potential therapeutic option in preventing symptom exacerbation in TRS. However, there is limited evidence supporting the role of M-ECT in TRS. Aim: To evaluate the efficacy and safety of maintenance electroconvulsive therapy in patients with TRS. Methodology: Sociodemographic details, illness characteristics, details of M-ECT procedure, adverse events, and course of the illness were evaluated using a retrospective chart review at a tertiary care psychiatry centre in south India. Scores on Clinical Global Impression-Severity (CGI-S), Social and Occupational Functioning Assessment Scale (SOFAS), and Hindi Mental Status Examination were compared before and after the course of M-ECT. Results: Seven male and three female patients received M-ECT in the last eight years (range of 22–172 sessions). There was a reduction in hospitalizations for acute exacerbation and significant improvement in the patient's overall functioning without significant adverse effects. Conclusion: Maintenance ECT can be a safe and effective treatment option for achieving symptom control in the long-term management of refractory schizophrenia. Controlled trials are needed in this area for further evidence.
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U2 - 10.1016/j.ajp.2022.103132
DO - 10.1016/j.ajp.2022.103132
M3 - Article
C2 - 35533602
AN - SCOPUS:85129845385
SN - 1876-2018
VL - 73
SP - 103132
JO - Asian Journal of Psychiatry
JF - Asian Journal of Psychiatry
M1 - 103132
ER -
