Efficacy and safety of maintenance electroconvulsive therapy (M-ECT) in treatment-resistant schizophrenia: A case series

Abhiram Narasimhan Purohith, Shalaka Anand Chatorikar, Samir Kumar Praharaj, Rajeshkrishna Panambur Bhandary, Podila Satya Venkata Narasimha Sharma

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2 Citations (SciVal)


Background: Treatment-resistant schizophrenia (TRS) is a substantial burden to patients, caregivers, and the treating team. There is a lack of robust evidence to support the efficacy of various pharmacological and non-pharmacological measures to augment clozapine in this population. When used in conjunction with clozapine or other combination antipsychotic regimens, maintenance electroconvulsive therapy (M-ECT) can be a potential therapeutic option in preventing symptom exacerbation in TRS. However, there is limited evidence supporting the role of M-ECT in TRS. Aim: To evaluate the efficacy and safety of maintenance electroconvulsive therapy in patients with TRS. Methodology: Sociodemographic details, illness characteristics, details of M-ECT procedure, adverse events, and course of the illness were evaluated using a retrospective chart review at a tertiary care psychiatry centre in south India. Scores on Clinical Global Impression-Severity (CGI-S), Social and Occupational Functioning Assessment Scale (SOFAS), and Hindi Mental Status Examination were compared before and after the course of M-ECT. Results: Seven male and three female patients received M-ECT in the last eight years (range of 22–172 sessions). There was a reduction in hospitalizations for acute exacerbation and significant improvement in the patient's overall functioning without significant adverse effects. Conclusion: Maintenance ECT can be a safe and effective treatment option for achieving symptom control in the long-term management of refractory schizophrenia. Controlled trials are needed in this area for further evidence.

Original languageEnglish
Article number103132
Pages (from-to)103132
JournalAsian Journal of Psychiatry
Publication statusPublished - 07-2022

All Science Journal Classification (ASJC) codes

  • Psychology(all)
  • Psychiatry and Mental health


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