TY - JOUR
T1 - Efficacy of anti-staphylococcal protein P128 for the treatment of canine pyoderma
T2 - Potential applications
AU - Junjappa, Raghu Patil
AU - Desai, Srividya Narayanamurthy
AU - Roy, Panchali
AU - Narasimhaswamy, Nagalakshmi
AU - Raj, Juliet Roshini Mohan
AU - Durgaiah, Murali
AU - Vipra, Aradhana
AU - Bhat, Udaya Ravi
AU - Satyanarayana, Smitha Komarla
AU - Shankara, Nandini
AU - Basingi, Suneelkumar Muragesh
AU - Bhat, Jagadeesh Janardhan
AU - Hariharan, Sukumar
AU - Sriram, Bharathi
AU - Padmanabhan, Sriram
PY - 2013/9/1
Y1 - 2013/9/1
N2 - In this study, we demonstrate the antibacterial activity of P128 on Staphylococcus isolates responsible for canine pyoderma. Eighty seven swabs were collected from dogs suffering from pyoderma and subjected to antibiotic sensitivity test and 46 Staphylococcus strains were isolated and characterized. In-vitro antimicrobial susceptibility testing with P128 was done by Minimum Inhibitory Concentration (MIC) method as per CLSI guidelines. All the Staphylococci isolated from the dogs with pyoderma, although showed resistance to various antibiotics tested, were lysed by P128. Clinical efficacy of P128 was examined in 17 dogs with pyoderma by application of the P128 hydrogel twice daily for 8 days and the results indicated complete healing of all the lesions of all the dogs under treatment. Under the conditions of this study, P128 was found to be a potent convenient proteinaceous drug for the treatment of staphylococcal pyoderma in dogs.
AB - In this study, we demonstrate the antibacterial activity of P128 on Staphylococcus isolates responsible for canine pyoderma. Eighty seven swabs were collected from dogs suffering from pyoderma and subjected to antibiotic sensitivity test and 46 Staphylococcus strains were isolated and characterized. In-vitro antimicrobial susceptibility testing with P128 was done by Minimum Inhibitory Concentration (MIC) method as per CLSI guidelines. All the Staphylococci isolated from the dogs with pyoderma, although showed resistance to various antibiotics tested, were lysed by P128. Clinical efficacy of P128 was examined in 17 dogs with pyoderma by application of the P128 hydrogel twice daily for 8 days and the results indicated complete healing of all the lesions of all the dogs under treatment. Under the conditions of this study, P128 was found to be a potent convenient proteinaceous drug for the treatment of staphylococcal pyoderma in dogs.
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U2 - 10.1007/s11259-013-9565-y
DO - 10.1007/s11259-013-9565-y
M3 - Article
C2 - 23661290
AN - SCOPUS:84882880135
SN - 0165-7380
VL - 37
SP - 217
EP - 228
JO - Veterinary Research Communications
JF - Veterinary Research Communications
IS - 3
ER -