TY - JOUR
T1 - EFFICACY OF DEXAMETHASONE PULSE THERAPY IN PROGRESSIVE SYSTEMIC SCLEROSIS
AU - PAI, BALLAMBAT SATHISH
AU - SRINIVAS, CHAKRAVARTHI R.
AU - SABITHA, LAKSHMINARAYANAN
AU - SHENOI, SHRUTAKIRTHI D.
AU - BALACHANDRAN, CHANDRASEKHARAN N.
AU - ACHARYA, SANDHYA
PY - 1995/1/1
Y1 - 1995/1/1
N2 - Background. Systemic sclerosis is a disease of unknown etiology for which no specific treatment is effective. Pulse therapy with corticosteroids has been tried for various autoimmune disorders with minimal side effects. We undertook this study to determine the efficacy of dexamethasone pulse therapy in progressive systemic sclerosis (PSS). Methods. Five women with PSS between the ages 30 and 60 years, received 100 mg dexamethasone in 500 mL of 5% dextrose by slow intravenous infusion over 3 hours for 3 consecutive days, once a month. Results. All patients had symptomatic and clinical improvement. The vital capacity improved in three and posttreatment histopathologic regression was seen in two patients. Conclusions. Dexamethasone pulse therapy may provide an additional option for treating systemic sclerosis.
AB - Background. Systemic sclerosis is a disease of unknown etiology for which no specific treatment is effective. Pulse therapy with corticosteroids has been tried for various autoimmune disorders with minimal side effects. We undertook this study to determine the efficacy of dexamethasone pulse therapy in progressive systemic sclerosis (PSS). Methods. Five women with PSS between the ages 30 and 60 years, received 100 mg dexamethasone in 500 mL of 5% dextrose by slow intravenous infusion over 3 hours for 3 consecutive days, once a month. Results. All patients had symptomatic and clinical improvement. The vital capacity improved in three and posttreatment histopathologic regression was seen in two patients. Conclusions. Dexamethasone pulse therapy may provide an additional option for treating systemic sclerosis.
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U2 - 10.1111/j.1365-4362.1995.tb04664.x
DO - 10.1111/j.1365-4362.1995.tb04664.x
M3 - Article
C2 - 8537165
AN - SCOPUS:0028847331
SN - 0011-9059
VL - 34
SP - 726
EP - 728
JO - International Journal of Dermatology
JF - International Journal of Dermatology
IS - 10
ER -