Electric field mapping and structure-activity relationships for some neurotransmitters: serotonin congeners

C. Santhosh; P. C. Mishra

doi:10.1016/0166-1280(94)80205-X

Electric field mapping and structure-activity relationships for some neurotransmitters: serotonin congeners

C. Santhosh^*
, P. C. Mishra

^*Corresponding author for this work

Manipal Institute of Applied Physics (MIAP)

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Electric field maps of neutral and cationic forms of 5-hydroxytryptamine (serotonin), 5-chlorotryptamine, 6-hydroxytryptamine and 4-hydroxytryptamine have been studied. The binding of these species through the substituent at position 5 and the amino group, with the receptor, are shown to be of crucial significance. A relationship between the observed potencies of the different compounds and electric fields near the substituent at position 5, has been shown to exist.

Original language	English
Pages (from-to)	77-81
Number of pages	5
Journal	Journal of Molecular Structure: THEOCHEM
Volume	306
Issue number	1
DOIs	https://doi.org/10.1016/0166-1280(94)80205-X
Publication status	Published - 20-03-1994

All Science Journal Classification (ASJC) codes

Biochemistry
Condensed Matter Physics
Physical and Theoretical Chemistry

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10.1016/0166-1280(94)80205-X

Cite this

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abstract = "Electric field maps of neutral and cationic forms of 5-hydroxytryptamine (serotonin), 5-chlorotryptamine, 6-hydroxytryptamine and 4-hydroxytryptamine have been studied. The binding of these species through the substituent at position 5 and the amino group, with the receptor, are shown to be of crucial significance. A relationship between the observed potencies of the different compounds and electric fields near the substituent at position 5, has been shown to exist.",

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AB - Electric field maps of neutral and cationic forms of 5-hydroxytryptamine (serotonin), 5-chlorotryptamine, 6-hydroxytryptamine and 4-hydroxytryptamine have been studied. The binding of these species through the substituent at position 5 and the amino group, with the receptor, are shown to be of crucial significance. A relationship between the observed potencies of the different compounds and electric fields near the substituent at position 5, has been shown to exist.

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Electric field mapping and structure-activity relationships for some neurotransmitters: serotonin congeners

Abstract

All Science Journal Classification (ASJC) codes

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