TY - JOUR
T1 - Electrospun gelatin nanofibers as drug carrier
T2 - Effect of crosslinking on sustained release
AU - Laha, Anindita
AU - Sharma, Chandra S.
AU - Majumdar, Saptarshi
N1 - Publisher Copyright:
© 2015 Elsevier Ltd. All rights reserved.
PY - 2016
Y1 - 2016
N2 - This study aims to develop a natural biopolymer based nanofabric as an oral drug carrier to deliver a model hydrophobic drug (piperine) in a sustained and controlled manner over prolonged time. For that, we electrospun gelatin nanofabric mesh followed by crosslinking using saturated vapor of glutaraldehyde (GTA) for 8 mins to improve the water resistive properties. Later, we investigated the effect of different crosslinking strategies and found that layer-by-layer crosslinking not only provides an improved structural integrity, thermal and chemical stability of drug but also yields a tight control over sustained drug release up to 8 h.
AB - This study aims to develop a natural biopolymer based nanofabric as an oral drug carrier to deliver a model hydrophobic drug (piperine) in a sustained and controlled manner over prolonged time. For that, we electrospun gelatin nanofabric mesh followed by crosslinking using saturated vapor of glutaraldehyde (GTA) for 8 mins to improve the water resistive properties. Later, we investigated the effect of different crosslinking strategies and found that layer-by-layer crosslinking not only provides an improved structural integrity, thermal and chemical stability of drug but also yields a tight control over sustained drug release up to 8 h.
UR - https://www.scopus.com/pages/publications/85001913331
UR - https://www.scopus.com/pages/publications/85001913331#tab=citedBy
U2 - 10.1016/j.matpr.2016.10.031
DO - 10.1016/j.matpr.2016.10.031
M3 - Article
AN - SCOPUS:85001913331
SN - 2214-7853
VL - 3
SP - 3484
EP - 3491
JO - Materials Today: Proceedings
JF - Materials Today: Proceedings
IS - 10
ER -