TY - JOUR
T1 - Emerging Biomarkers and Innovative Therapeutic Strategies in Diabetic Kidney Disease
T2 - A Pathway to Precision Medicine
AU - Shetty, Sahana
AU - Suvarna, Renuka
AU - Awasthi, Avivar
AU - Bhojaraja, Mohan V.
AU - Pappachan, Joseph M.
N1 - Publisher Copyright:
© 2025 by the authors.
PY - 2025/4
Y1 - 2025/4
N2 - Diabetes mellitus (DM) has emerged as the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) globally in recent years. Diabetic nephropathy (DN), or diabetic kidney disease (DKD) that occurs as a direct consequence of DM, has complex pathophysiological mechanisms, such as various inflammatory processes and genetic and epigenetic factors, often accentuated by comorbid illnesses like hypertension and dyslipidemia. Therefore, management of DKD involves targeting these etio-pathological processes. Various medications with remarkable disease modifying properties have been introduced for treatment of DN in recent years. We update the current and future diagnostic and therapeutic landscapes against DKD in this article.
AB - Diabetes mellitus (DM) has emerged as the most common cause of chronic kidney disease (CKD) and end-stage renal disease (ESRD) globally in recent years. Diabetic nephropathy (DN), or diabetic kidney disease (DKD) that occurs as a direct consequence of DM, has complex pathophysiological mechanisms, such as various inflammatory processes and genetic and epigenetic factors, often accentuated by comorbid illnesses like hypertension and dyslipidemia. Therefore, management of DKD involves targeting these etio-pathological processes. Various medications with remarkable disease modifying properties have been introduced for treatment of DN in recent years. We update the current and future diagnostic and therapeutic landscapes against DKD in this article.
UR - https://www.scopus.com/pages/publications/105003649405
UR - https://www.scopus.com/pages/publications/105003649405#tab=citedBy
U2 - 10.3390/diagnostics15080973
DO - 10.3390/diagnostics15080973
M3 - Review article
AN - SCOPUS:105003649405
SN - 2075-4418
VL - 15
JO - Diagnostics
JF - Diagnostics
IS - 8
M1 - 973
ER -
