TY - JOUR
T1 - Emerging trends in chitosan based colloidal drug delivery systems
T2 - A translational journey from research to practice
AU - Manohar, Mahadev
AU - Shetty, Amitha
AU - Lobo, Cynthia Lizzie
AU - Jain, Praneetha
AU - Hebbar, Srinivas
AU - Dhas, Namdev
AU - Sutar, Kishori P.
AU - Sukeewandhi, Johan
AU - Perumalsamy, Haribalan
AU - Balusamy, Sri Renukadevi
AU - Jamous, Yahya F.
AU - Dubey, Akhilesh
AU - El-Zahaby, Sally A.
N1 - Publisher Copyright:
© 2025 Elsevier Ltd
PY - 2025/7/15
Y1 - 2025/7/15
N2 - Chitosan, a natural polymer derived from chitin, has garnered significant interest in pharmaceutical and biomedical applications due to its distinctive properties, such as controlled drug release, mucoadhesive capabilities, in situ gelling property, enhancement of permeation, and efflux pump inhibitory effect. In this review, various types of chitosan based colloidal drug delivery systems such as vesicular, and particulate systems were discussed along with their role in pre-clinical biomedical applications. Some important clinical applications of chitosan-based drug delivery systems in treating major chronic diseases were also discussed. Using Chitosan in delivery of drugs and gene therapy had many beneficial outcomes, however, obtaining clinical acceptance and regulatory approval requires a careful approach for proving efficacy and safety. In order to present the current status of chitosan-based drug delivery systems, filled patents employing chitosan derivatives were also part of this review. This will help forward the use of chitosan-based drug delivery system from research to practice. Finally, the future prospects for chitosan-based delivery systems were discussed.
AB - Chitosan, a natural polymer derived from chitin, has garnered significant interest in pharmaceutical and biomedical applications due to its distinctive properties, such as controlled drug release, mucoadhesive capabilities, in situ gelling property, enhancement of permeation, and efflux pump inhibitory effect. In this review, various types of chitosan based colloidal drug delivery systems such as vesicular, and particulate systems were discussed along with their role in pre-clinical biomedical applications. Some important clinical applications of chitosan-based drug delivery systems in treating major chronic diseases were also discussed. Using Chitosan in delivery of drugs and gene therapy had many beneficial outcomes, however, obtaining clinical acceptance and regulatory approval requires a careful approach for proving efficacy and safety. In order to present the current status of chitosan-based drug delivery systems, filled patents employing chitosan derivatives were also part of this review. This will help forward the use of chitosan-based drug delivery system from research to practice. Finally, the future prospects for chitosan-based delivery systems were discussed.
UR - https://www.scopus.com/pages/publications/105002830902
UR - https://www.scopus.com/pages/publications/105002830902#tab=citedBy
U2 - 10.1016/j.carbpol.2025.123604
DO - 10.1016/j.carbpol.2025.123604
M3 - Review article
AN - SCOPUS:105002830902
SN - 0144-8617
VL - 360
JO - Carbohydrate Polymers
JF - Carbohydrate Polymers
M1 - 123604
ER -