Enhanced antitumour efficacy of methotrexate poly(lactic-co-glycolic) acid injectable gel implants in mice bearing sarcoma-180

U. V. Singh; N. Udupa; R. Kamath; P. Umadevi

Enhanced antitumour efficacy of methotrexate poly(lactic-co-glycolic) acid injectable gel implants in mice bearing sarcoma-180

U. V. Singh, N. Udupa, R. Kamath, P. Umadevi

Research output: Contribution to journal › Article › peer-review

Abstract

Injectable gel implants using poly(lactic-co-glycolic) acid (PLGA) for methotrexate were prepared. In-vitro release was observed for 10-12 days and was dependent on PLGA concentration. The antitumour efficacy in mice bearing sarcoma-180 was improved as revealed by the volume doubling time. The drug plasma levels were sustained for more than 2 weeks.

Original language	English
Pages (from-to)	133-136
Number of pages	4
Journal	Pharmaceutical Sciences
Volume	3
Issue number	3
Publication status	Published - 1997

All Science Journal Classification (ASJC) codes

Pharmaceutical Science

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title = "Enhanced antitumour efficacy of methotrexate poly(lactic-co-glycolic) acid injectable gel implants in mice bearing sarcoma-180",

abstract = "Injectable gel implants using poly(lactic-co-glycolic) acid (PLGA) for methotrexate were prepared. In-vitro release was observed for 10-12 days and was dependent on PLGA concentration. The antitumour efficacy in mice bearing sarcoma-180 was improved as revealed by the volume doubling time. The drug plasma levels were sustained for more than 2 weeks.",

author = "Singh, {U. V.} and N. Udupa and R. Kamath and P. Umadevi",

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AU - Singh, U. V.

AU - Udupa, N.

AU - Kamath, R.

AU - Umadevi, P.

N1 - cited By 4

PY - 1997

Y1 - 1997

N2 - Injectable gel implants using poly(lactic-co-glycolic) acid (PLGA) for methotrexate were prepared. In-vitro release was observed for 10-12 days and was dependent on PLGA concentration. The antitumour efficacy in mice bearing sarcoma-180 was improved as revealed by the volume doubling time. The drug plasma levels were sustained for more than 2 weeks.

AB - Injectable gel implants using poly(lactic-co-glycolic) acid (PLGA) for methotrexate were prepared. In-vitro release was observed for 10-12 days and was dependent on PLGA concentration. The antitumour efficacy in mice bearing sarcoma-180 was improved as revealed by the volume doubling time. The drug plasma levels were sustained for more than 2 weeks.

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M3 - Article

AN - SCOPUS:0031417755

SN - 0022-3573

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SP - 133

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JO - Journal of Pharmacy and Pharmacology

JF - Journal of Pharmacy and Pharmacology

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ER -

Enhanced antitumour efficacy of methotrexate poly(lactic-co-glycolic) acid injectable gel implants in mice bearing sarcoma-180

Abstract

All Science Journal Classification (ASJC) codes

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