Enhancing prostate cancer detection: The role of b-value and apparent diffusion coefficient in DWI

Background: Magnetic Resonance Imaging (MRI) is a highly effective tool for the detection of prostate cancer (PCa). Diffusion-weighted MRI (DW-MRI) is a sensitive technique that depends on the b value and apparent diffusion coefficient (ADC) value for the diagnosis of PCa. The main objective of this study was to determine the optimal b-value and apparent diffusion coefficient (ADC) value in DW-MRI for the diagnosis of prostate cancer. Methods: A prospective study including 26 male participants were conducted. MRI examinations were performed with T2 fat saturation sequences, and Diffusion weighted imaging (DWI) sequences with b-values (800, 1000, 1500, and 2000 mm ²/s) were used, and the corresponding ADC maps were calculated. Qualitative and quantitative analyses were conducted. Results: According to the present study, a b-value of 0,1500 mm ²/s exhibited the highest Signal-to-Noise Ratio (SNR), and Signal Intensity Ratio (SIR). Area Under the Curve (AUC) for 0,1500 mm ²/s was 0.80, indicating a high diagnostic accuracy for prostate cancer. Conclusion: DWI with a b-value of 1500 mm ²/s provides good diagnostic accuracy for differential diagnosis of prostate lesions. DWI is a crucial sequence in multiparametric MRI of the prostate and offers detailed information that enhances the accuracy of prostate cancer diagnosis and management.