Environment signal dependent biocontainment systems for engineered organisms: Leveraging triggered responses and combinatorial systems

Shreya Varma, Khushi Ash Gulati, Janani Sriramakrishnan, Riyaa Kedar Ganla, Ritu Raval*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

Abstract

As synthetic biology advances, the necessity for robust biocontainment strategies for genetically engineered organisms (GEOs) grows increasingly critical to mitigate biosafety risks related to their potential environmental release. This paper aims to evaluate environment signal-dependent biocontainment systems for engineered organisms, focusing specifically on leveraging triggered responses and combinatorial systems. There are different types of triggers—chemical, light, temperature, and pH—this review illustrates how these systems can be designed to respond to environmental signals, ensuring a higher safety profile. It also focuses on combinatorial biocontainment to avoid consequences of unintended GEO release into an external environment. Case studies are discussed to demonstrate the practical applications of these systems in real-world scenarios.

Original languageEnglish
Pages (from-to)356-364
Number of pages9
JournalSynthetic and Systems Biotechnology
Volume10
Issue number2
DOIs
Publication statusPublished - 06-2025

All Science Journal Classification (ASJC) codes

  • Structural Biology
  • Biomedical Engineering
  • Applied Microbiology and Biotechnology
  • Genetics

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