TY - JOUR
T1 - Environment signal dependent biocontainment systems for engineered organisms
T2 - Leveraging triggered responses and combinatorial systems
AU - Varma, Shreya
AU - Gulati, Khushi Ash
AU - Sriramakrishnan, Janani
AU - Ganla, Riyaa Kedar
AU - Raval, Ritu
N1 - Publisher Copyright:
© 2024 The Authors
PY - 2025/6
Y1 - 2025/6
N2 - As synthetic biology advances, the necessity for robust biocontainment strategies for genetically engineered organisms (GEOs) grows increasingly critical to mitigate biosafety risks related to their potential environmental release. This paper aims to evaluate environment signal-dependent biocontainment systems for engineered organisms, focusing specifically on leveraging triggered responses and combinatorial systems. There are different types of triggers—chemical, light, temperature, and pH—this review illustrates how these systems can be designed to respond to environmental signals, ensuring a higher safety profile. It also focuses on combinatorial biocontainment to avoid consequences of unintended GEO release into an external environment. Case studies are discussed to demonstrate the practical applications of these systems in real-world scenarios.
AB - As synthetic biology advances, the necessity for robust biocontainment strategies for genetically engineered organisms (GEOs) grows increasingly critical to mitigate biosafety risks related to their potential environmental release. This paper aims to evaluate environment signal-dependent biocontainment systems for engineered organisms, focusing specifically on leveraging triggered responses and combinatorial systems. There are different types of triggers—chemical, light, temperature, and pH—this review illustrates how these systems can be designed to respond to environmental signals, ensuring a higher safety profile. It also focuses on combinatorial biocontainment to avoid consequences of unintended GEO release into an external environment. Case studies are discussed to demonstrate the practical applications of these systems in real-world scenarios.
UR - http://www.scopus.com/inward/record.url?scp=85213080398&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85213080398&partnerID=8YFLogxK
U2 - 10.1016/j.synbio.2024.12.005
DO - 10.1016/j.synbio.2024.12.005
M3 - Review article
AN - SCOPUS:85213080398
SN - 2405-805X
VL - 10
SP - 356
EP - 364
JO - Synthetic and Systems Biotechnology
JF - Synthetic and Systems Biotechnology
IS - 2
ER -