Epigenetics mechanisms and degenerative diseases

Joshi K, Smitha Bhat, Deshpande P, Sule M, Satyamoorthy Kapaettu

    Research output: Contribution to journalArticlepeer-review


    Epigenetic regulations are heritable changes in gene expression that occur in the absence of alterations in DNA sequences. Various epigenetic mechanisms in- clude histone modifications and DNA methylations. In this review, we examine methods to study DNA methylations and their contribution to degenerative diseases by mediating the complex gene-by-environ- ment interactions. Such epigenetic modifications des- pite being heritable and stably maintained are also potentially reversible and there is scope for the de-velopment of epigenetic therapies for this disease
    Original languageEnglish
    JournalOpen Journal of Genetics
    Publication statusPublished - 2012


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