TY - JOUR
T1 - Epithelial-Mesenchymal Transition and its Role in Renal Fibrogenesis
AU - Singh, Brij Mohan Kumar
AU - Mathew, Mary
N1 - Funding Information:
This research received no external funding.
Publisher Copyright:
© 2022. by the authors. Submitted for possible open access publication under the terms and conditions of the Creative Commons Attribution (CC BY NC) license (https://creativecommons.org/licenses/by-nc/4.0/).
PY - 2022
Y1 - 2022
N2 - Renal fibrosis in chronic renal failure poses a major challenge with regard to providing specific therapeutic strategies. The current hypothesis of the epithelial-mesenchymal transition (EMT) in renal fibrosis proposes that matrix producing fibroblasts and myofibroblasts generated in the diseased kidney causes fibrosis. This paper explores the pathogenetic mechanisms, the role of EMT in renal fibrogenesis in chronic kidney disease, biomarkers, and EMT related anti-fibrotic therapy.
AB - Renal fibrosis in chronic renal failure poses a major challenge with regard to providing specific therapeutic strategies. The current hypothesis of the epithelial-mesenchymal transition (EMT) in renal fibrosis proposes that matrix producing fibroblasts and myofibroblasts generated in the diseased kidney causes fibrosis. This paper explores the pathogenetic mechanisms, the role of EMT in renal fibrogenesis in chronic kidney disease, biomarkers, and EMT related anti-fibrotic therapy.
UR - http://www.scopus.com/inward/record.url?scp=85136654534&partnerID=8YFLogxK
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U2 - 10.1590/1678-4324-2022210260
DO - 10.1590/1678-4324-2022210260
M3 - Article
AN - SCOPUS:85136654534
SN - 1516-8913
VL - 65
JO - Arquivos de Biologia e Technologia
JF - Arquivos de Biologia e Technologia
M1 - e22210260
ER -