Epithelial-Mesenchymal Transition and its Role in Renal Fibrogenesis

Brij Mohan Kumar Singh; Mary Mathew

doi:10.1590/1678-4324-2022210260

Epithelial-Mesenchymal Transition and its Role in Renal Fibrogenesis

Brij Mohan Kumar Singh
, Mary Mathew^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

4 Citations (Scopus)

Abstract

Renal fibrosis in chronic renal failure poses a major challenge with regard to providing specific therapeutic strategies. The current hypothesis of the epithelial-mesenchymal transition (EMT) in renal fibrosis proposes that matrix producing fibroblasts and myofibroblasts generated in the diseased kidney causes fibrosis. This paper explores the pathogenetic mechanisms, the role of EMT in renal fibrogenesis in chronic kidney disease, biomarkers, and EMT related anti-fibrotic therapy.

Original language	English
Article number	e22210260
Journal	Brazilian Archives of Biology and Technology
Volume	65
DOIs	https://doi.org/10.1590/1678-4324-2022210260
Publication status	Published - 2022

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10.1590/1678-4324-2022210260

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title = "Epithelial-Mesenchymal Transition and its Role in Renal Fibrogenesis",

abstract = "Renal fibrosis in chronic renal failure poses a major challenge with regard to providing specific therapeutic strategies. The current hypothesis of the epithelial-mesenchymal transition (EMT) in renal fibrosis proposes that matrix producing fibroblasts and myofibroblasts generated in the diseased kidney causes fibrosis. This paper explores the pathogenetic mechanisms, the role of EMT in renal fibrogenesis in chronic kidney disease, biomarkers, and EMT related anti-fibrotic therapy.",

author = "Singh, \{Brij Mohan Kumar\} and Mary Mathew",

note = "Funding Information: This research received no external funding. Publisher Copyright: {\textcopyright} 2022. by the authors. Submitted for possible open access publication under the terms and conditions of the Creative Commons Attribution (CC BY NC) license (https://creativecommons.org/licenses/by-nc/4.0/).",

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T1 - Epithelial-Mesenchymal Transition and its Role in Renal Fibrogenesis

AU - Singh, Brij Mohan Kumar

AU - Mathew, Mary

N1 - Funding Information: This research received no external funding. Publisher Copyright: © 2022. by the authors. Submitted for possible open access publication under the terms and conditions of the Creative Commons Attribution (CC BY NC) license (https://creativecommons.org/licenses/by-nc/4.0/).

PY - 2022

Y1 - 2022

N2 - Renal fibrosis in chronic renal failure poses a major challenge with regard to providing specific therapeutic strategies. The current hypothesis of the epithelial-mesenchymal transition (EMT) in renal fibrosis proposes that matrix producing fibroblasts and myofibroblasts generated in the diseased kidney causes fibrosis. This paper explores the pathogenetic mechanisms, the role of EMT in renal fibrogenesis in chronic kidney disease, biomarkers, and EMT related anti-fibrotic therapy.

AB - Renal fibrosis in chronic renal failure poses a major challenge with regard to providing specific therapeutic strategies. The current hypothesis of the epithelial-mesenchymal transition (EMT) in renal fibrosis proposes that matrix producing fibroblasts and myofibroblasts generated in the diseased kidney causes fibrosis. This paper explores the pathogenetic mechanisms, the role of EMT in renal fibrogenesis in chronic kidney disease, biomarkers, and EMT related anti-fibrotic therapy.

UR - https://www.scopus.com/pages/publications/85136654534

UR - https://www.scopus.com/pages/publications/85136654534#tab=citedBy

U2 - 10.1590/1678-4324-2022210260

DO - 10.1590/1678-4324-2022210260

M3 - Article

AN - SCOPUS:85136654534

SN - 1516-8913

VL - 65

JO - Brazilian Archives of Biology and Technology

JF - Brazilian Archives of Biology and Technology

M1 - e22210260

ER -

Epithelial-Mesenchymal Transition and its Role in Renal Fibrogenesis

Abstract

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